613560 TMPyP4 - CAS 36951-72-1 - Calbiochem

613560
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₄₄H₃₈N₈ · C₂₈H₂₈O₁₂S₄ 36951-72-1

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613560-25MG
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      Plastic ampoule 25 mg
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      Description
      OverviewA potent inhibitor of human telomerase (IC50 = 6.5 µM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. Fluoresces intensely in the presence of quadruplex DNA.
      Catalogue Number613560
      Brand Family Calbiochem®
      Synonymsmeso-5,10,15,20-Tetrakis-(N-methyl-4-pyridyl)porphine, Tetratosylate
      References
      ReferencesYamashita, T., et al. 2005. Bioorg. Med. Chem. 13, 2433.
      Izbicka, E., et al. 1999. Cancer Res. 59, 639.
      Anantha, N.V., et al. 1998. Biochemistry 37, 2709.
      Arthanari, H., et al. 1998. Nucleic Acids Res. 26, 3724.
      Wheelhouse, R.T., et al. 1998. J. Am. Chem. Soc. 120, 3261.
      Product Information
      CAS number36951-72-1
      ATP CompetitiveN
      FormPurple solid
      Hill FormulaC₄₄H₃₈N₈ · C₂₈H₂₈O₁₂S₄
      Chemical formulaC₄₄H₃₈N₈ · C₂₈H₂₈O₁₂S₄
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targethuman telomerase
      Primary Target IC<sub>50</sub>6.5 µM inhibiting human telomerase
      Purity≥90% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      TMPyP4 - CAS 36951-72-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      TMPyP4 - CAS 36951-72-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      613560

      References

      Reference overview
      Yamashita, T., et al. 2005. Bioorg. Med. Chem. 13, 2433.
      Izbicka, E., et al. 1999. Cancer Res. 59, 639.
      Anantha, N.V., et al. 1998. Biochemistry 37, 2709.
      Arthanari, H., et al. 1998. Nucleic Acids Res. 26, 3724.
      Wheelhouse, R.T., et al. 1998. J. Am. Chem. Soc. 120, 3261.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-December-2018 JSW
      Synonymsmeso-5,10,15,20-Tetrakis-(N-methyl-4-pyridyl)porphine, Tetratosylate
      DescriptionA potent inhibitor of human telomerase (IC50 = 6.5 µM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. Fluoresces highly in the presence of quadruplex DNA.
      FormPurple solid
      CAS number36951-72-1
      Chemical formulaC₄₄H₃₈N₈ · C₂₈H₂₈O₁₂S₄
      Structure formulaStructure formula
      Purity≥90% by TLC
      SolubilityH₂O (1 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesYamashita, T., et al. 2005. Bioorg. Med. Chem. 13, 2433.
      Izbicka, E., et al. 1999. Cancer Res. 59, 639.
      Anantha, N.V., et al. 1998. Biochemistry 37, 2709.
      Arthanari, H., et al. 1998. Nucleic Acids Res. 26, 3724.
      Wheelhouse, R.T., et al. 1998. J. Am. Chem. Soc. 120, 3261.