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616454 TGF-β RI Kinase Inhibitor IV - CAS 909910-43-6 - Calbiochem

TGF-β RI Kinase Inhibitor IV, CAS 909910-43-6, is a cell-permeable, selective inhibitor of ALK-4/5/7-mediated signaling (IC₅₀ = 45, 12, and 7.5 nM, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Transforming Growth Factor-β Type I Receptor Kinase Inhibitor IV, 3-(6-Methylpyridin-2-yl)-4-(4-quinolyl)-1-phenylthiocarbamoyl-1H-pyrazole, A-83-01, ALK5 Inhibitor IV

Primary Target: ALK-4/5/7
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
909910-43-6C₂₅H₁₉N₅S

Products

Catalog NumberPackaging Qty/Pack
616454-2MG Plastic ampoule 2 mg
Description
OverviewA cell-permeable trisubstituted pyrazole compound that has been shown to selectively inhibit ALK-4/5/7-mediated (IC50 = 45, 12, and 7.5 nM, respectively, in luciferase transcription activity assays), but not ALK-1/2/3/6-mediated cellular signaling in Mv1Lu R4-2 transfectants expressing the individual Type I TGF-β receptors. Inhibits TGF-β-induced Smad2-phosphorylation in HaCaT cells and epithelial-to-mesenchymal transition in NMuMG cells at a concentration of 1 µM.
Catalogue Number616454
Brand Family Calbiochem®
SynonymsTransforming Growth Factor-β Type I Receptor Kinase Inhibitor IV, 3-(6-Methylpyridin-2-yl)-4-(4-quinolyl)-1-phenylthiocarbamoyl-1H-pyrazole, A-83-01, ALK5 Inhibitor IV
References
ReferencesTojo, M., et al. 2005. Cancer Sci. 96, 791.
Product Information
CAS number909910-43-6
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₂₅H₁₉N₅S
Chemical formulaC₂₅H₁₉N₅S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
Biological Information
Primary TargetALK-4/5/7
Primary Target IC<sub>50</sub>45, 12, and 7.5 nM, respectively, in inhibit ALK-4/5/7-mediated luciferase transcription activity assays
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
616454-2MG 04055977185867

Documentation

TGF-β RI Kinase Inhibitor IV - CAS 909910-43-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

TGF-β RI Kinase Inhibitor IV - CAS 909910-43-6 - Calbiochem Certificates of Analysis

TitleLot Number
616454

References

Reference overview
Tojo, M., et al. 2005. Cancer Sci. 96, 791.

Brochure

Title
TGF-b Signaling: Dual Role in Tumor Suppression and Oncogenesis

Technical Info

Title
TGF-β Signaling: Dual Role in Tumor Suppression and Oncogenesis
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-January-2010 RFH
SynonymsTransforming Growth Factor-β Type I Receptor Kinase Inhibitor IV, 3-(6-Methylpyridin-2-yl)-4-(4-quinolyl)-1-phenylthiocarbamoyl-1H-pyrazole, A-83-01, ALK5 Inhibitor IV
DescriptionA cell-permeable trisubstituted pyrazole compound that has been shown to selectively inhibit ALK-4/5/7-mediated (IC50 = 45, 12, and 7.5 nM, respectively, in luciferase transcription activity assays), but not ALK-1/2/3/6-mediated cellular signaling in Mv1Lu R4-2 transfectants expressing the individual Type I TGF-β receptors. Inhibits TGF-β-induced Smad2-phosphorylation in HaCaT cells and epithelial-to-mesenchymal transition in NMuMG cells at a concentration of 1 µM.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number909910-43-6
Chemical formulaC₂₅H₁₉N₅S
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (20 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesTojo, M., et al. 2005. Cancer Sci. 96, 791.