504596 TCN-201 - CAS 852918-02-6 - Calbiochem

504596
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Key Specifications Table

Empirical FormulaCAS #
C₂₁H₁₇ClFN₃O₄S 852918-02-6

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      Glass bottle 5 mg
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      Description
      OverviewA negative allosteric modulator selective for NR2A containing NMDA receptors (pIC50 = 6.8 and <4.3 µM for NR2A and NR2B, respectively). No effect on NR2B-containing NMDA receptors with concentrations less than 50 mM. Inhibition on NR2A containing NMDA receptors is glycine (or D-serine)-binding, but not glutamate-binding, dependent.
      Catalogue Number504596
      Brand Family Calbiochem®
      SynonymsNMDA Antagonist X, 3-Chloro-4-fluoro-N-[(4-{[2-(phenylcarbonyl)hydrazino]carbonyl}phenyl)methyl]benzenesulfonamide
      References
      ReferencesBettini. E., et al. 2010. J. Pharm. Exp. Ther. 335, 644.
      Shin, A., et al. 2011. Br. J. Pharmacol. 166, 1002.
      Edman, S., et al. 2012. Neuropharmacology 63, 441.
      Hansen, K., et al. 2012. J. Neurosci. 32, 6197.
      Product Information
      CAS number852918-02-6
      FormWhite powder
      Hill FormulaC₂₁H₁₇ClFN₃O₄S
      Chemical formulaC₂₁H₁₇ClFN₃O₄S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNMDA receptors
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      TCN-201 - CAS 852918-02-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Bettini. E., et al. 2010. J. Pharm. Exp. Ther. 335, 644.
      Shin, A., et al. 2011. Br. J. Pharmacol. 166, 1002.
      Edman, S., et al. 2012. Neuropharmacology 63, 441.
      Hansen, K., et al. 2012. J. Neurosci. 32, 6197.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-June-2013 JSW
      SynonymsNMDA Antagonist X, 3-Chloro-4-fluoro-N-[(4-{[2-(phenylcarbonyl)hydrazino]carbonyl}phenyl)methyl]benzenesulfonamide
      DescriptionA negative allosteric modulator selective for NR2A containing NMDA receptors (pIC50 = 6.8 and <4.3 µM for NR2A and NR2B, respectively). No effect on NR2B-containing NMDA receptors with concentrations less than 50 mM. Inhibition on NR2A containing NMDA receptors is glycine (or D-serine)-binding, but not glutamate-binding, dependent.
      FormWhite powder
      CAS number852918-02-6
      Chemical formulaC₂₁H₁₇ClFN₃O₄S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBettini. E., et al. 2010. J. Pharm. Exp. Ther. 335, 644.
      Shin, A., et al. 2011. Br. J. Pharmacol. 166, 1002.
      Edman, S., et al. 2012. Neuropharmacology 63, 441.
      Hansen, K., et al. 2012. J. Neurosci. 32, 6197.