574776 Swinholide A, Theonella swinhoei - Calbiochem

574776
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₇₈H₁₃₂O₂₀

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      574776-10UG
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          Plastic ampoule 10 μg
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          Description
          OverviewA dimeric dilactone macrolide that is cytotoxic to a variety of cancer cell lines in vitro. Disrupts the actin cytoskeleton by sequestering actin dimers with a binding stoichiometry of 1:1, and rapidly severing F-actin. Also possesses antifungal properties.
          Catalogue Number574776
          Brand Family Calbiochem®
          References
          ReferencesSaito, S.Y., et al. 1998. J. Biochem. (Tokyo) 123, 571.
          Bubb, M.R., et al. 1995. J. Biol. Chem. 270, 3463.
          Kobayashi, M., et al. 1994. Chem. Pharm. Bull. 42, 19.
          Doi, M., et al. 1991. J. Org. Chem. 56, 3629.
          Product Information
          ATP CompetitiveN
          FormColorless oil
          Hill FormulaC₇₈H₁₃₂O₂₀
          Chemical formulaC₇₈H₁₃₂O₂₀
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetDisrupts the actin cytoskeleton
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Swinholide A, Theonella swinhoei - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Swinholide A, Theonella swinhoei - Calbiochem Certificates of Analysis

          TitleLot Number
          574776

          References

          Reference overview
          Saito, S.Y., et al. 1998. J. Biochem. (Tokyo) 123, 571.
          Bubb, M.R., et al. 1995. J. Biol. Chem. 270, 3463.
          Kobayashi, M., et al. 1994. Chem. Pharm. Bull. 42, 19.
          Doi, M., et al. 1991. J. Org. Chem. 56, 3629.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-September-2008 RFH
          DescriptionA dimeric dilactone macrolide isolated from the marine sponge Theonella swinhoei. Cytotoxic to a variety of cancer cell lines in vitro. Disrupts the actin cytoskeleton by sequestering actin dimers with a binding stoichiometry of 1:1, and rapidly severing F-actin. Also possesses antifungal activity.
          FormColorless oil
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₇₈H₁₃₂O₂₀
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityEthanol or acetone
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSaito, S.Y., et al. 1998. J. Biochem. (Tokyo) 123, 571.
          Bubb, M.R., et al. 1995. J. Biol. Chem. 270, 3463.
          Kobayashi, M., et al. 1994. Chem. Pharm. Bull. 42, 19.
          Doi, M., et al. 1991. J. Org. Chem. 56, 3629.