500614 Sigma-AldrichSurvivin Inhibitor III, LLP-3 - Calbiochem
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Primary Target:
survivin
Survivin Inhibitor III, LLP-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Survivin-Ran Interaction Blocker, LLP3, 4-(3,5-bis(Benzyloxy)phenyl)-6-(5-chloro-2-hydroxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
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Overview
Replacement Information |
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Key Specifications Table
Empirical Formula |
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C₃₂H₂₃ClN₂O₄ |
Pricing & Availability
Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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5.00614.0001 |
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Glass bottle | 10 mg |
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Description | |
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Overview | A cell-permeable, dihydropyridinone compound that selectively disrupts survivin-Ran interaction in cell-free binding assays (IC50 <0.3 µM) and in U87 glioma cells (by 55% in 24 h; 20 µM) via direct binding at survivin protein-protein interaction interface, while exhibiting much reduced or little potency against survivin-Smac/DIABLO, survivin-survivin, or XIAP-Smac/DIABLO interaction. LLP-3 treatment abrogates neurosphere formation in GMB cultures (IC50 ≤35 µM) by selectively depleting CD133+ GSC population via apoptosis induction. TMZ (Cat. No. 500609), in comparison, enriches GMB GSC population by preferentially eradicating non-GSC population. LLP-3 is also efficacious in treating human GMB xenograft in mice in vivo (25 mg/kg/day via i.p.). Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. |
Catalogue Number | 500614 |
Brand Family | Calbiochem® |
Synonyms | Survivin-Ran Interaction Blocker, LLP3, 4-(3,5-bis(Benzyloxy)phenyl)-6-(5-chloro-2-hydroxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile |
References | |
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References | Guvenc, H., et al. 2013. Clin. Cancer Res. 19, 1. |
Product Information | |
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Form | Yellow solid |
Hill Formula | C₃₂H₂₃ClN₂O₄ |
Chemical formula | C₃₂H₂₃ClN₂O₄ |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Applications |
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Biological Information | |
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Primary Target | survivin |
Purity | ≥99% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Dimensions |
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Materials Information |
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Toxicological Information |
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Safety Information according to GHS |
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Safety Information |
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Product Usage Statements |
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Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Transport Information |
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Supplemental Information |
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Specifications |
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Documentation
Survivin Inhibitor III, LLP-3 - Calbiochem SDS
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References
Reference overview |
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Guvenc, H., et al. 2013. Clin. Cancer Res. 19, 1. |
Data Sheet | ||||||||||||||||||||||||||||
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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