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505896 Sumanirole Maleate - CAS 179386-44-8 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
179386-44-8C₁₁H₁₃N₃O•C₄H₄O₄

Products

Catalog NumberPackaging Qty/Pack
5.05896.0001 Glass bottle 5 mg
Description
OverviewAn extremely selective dopamine D2 receptor agonist (Ki = 9 nM). Commonly used in Parkinson′s Disease models and to reproduce cocaine′s discriminative stimulus effects. Sumanirole has greater than 200-fold selectivity for the D2 receptor subtype versus the other dopamine receptor subtypes in radioligand binding assays. In cell-based assays, sumanirole is a fully efficacious agonist, with EC50 values between 17 and 75 nM. In animals, sumanirole elicits many physiological responses attributed to D2-like receptor function.
Catalogue Number505896
Brand Family Calbiochem®
SynonymsDopamine D₂ receptor Agonist, Sumanirole, PNU 95666, PNU95666
References
ReferencesAchat-Mendes, C. et al., 2010. J. Pharmacol. Exp. Ther. 334, 556.
McCall, R. B. et al., 2005. J. Pharmacol. Exp. Ther. 314, 1248.
Product Information
CAS number179386-44-8
FormOff-white solid
Hill FormulaC₁₁H₁₃N₃O•C₄H₄O₄
Chemical formulaC₁₁H₁₃N₃O•C₄H₄O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetD₂
Primary Target K<sub>i</sub>9nM
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.05896.0001 04055977262506

Documentation

Sumanirole Maleate - CAS 179386-44-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Achat-Mendes, C. et al., 2010. J. Pharmacol. Exp. Ther. 334, 556.
McCall, R. B. et al., 2005. J. Pharmacol. Exp. Ther. 314, 1248.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-November-2013 JSW
SynonymsDopamine D₂ receptor Agonist, Sumanirole, PNU 95666, PNU95666
DescriptionAn extremely selective dopamine D2 receptor agonist (Ki = 9 nM). Commonly used in Parkinson′s Disease models and to reproduce cocaine′s discriminative stimulus effects. Sumanirole has greater than 200-fold selectivity for the D2 receptor subtype versus the other dopamine receptor subtypes in radioligand binding assays. In cell-based assays, sumanirole is a fully efficacious agonist, with EC50 values between 17 and 75 nM. In animals, sumanirole elicits many physiological responses attributed to D2-like receptor function.
FormOff-white solid
CAS number179386-44-8
Chemical formulaC₁₁H₁₃N₃O•C₄H₄O₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (16 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesAchat-Mendes, C. et al., 2010. J. Pharmacol. Exp. Ther. 334, 556.
McCall, R. B. et al., 2005. J. Pharmacol. Exp. Ther. 314, 1248.