GF073 Stromal Cell-Derived Factor-1α Protein, Recombinant human

GF073
10 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Key ApplicationsSpeciesSourcePurity
      CULT Human E.coli Greater than 98% by SDS-PAGE and HPLC analysis
      Description
      Catalogue NumberGF073
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionStromal Cell-Derived Factor-1α Protein, Recombinant human
      OverviewStromal Cell-Derived Factor-1alpha (SDF1alpha) is a recently discovered protein belonging to the alpha-chemokine (C-X-C) family of cytokines. GF073 is a 8.0 kDa protein containing 68 amino acid residues.
      Alternate Names
      • SDF-1alpha
      References
      Product Information
      PresentationLyophilized protein with no additives.
      Quality LevelMQ100
      Applications
      ApplicationThe Stromal Cell-Derived Factor-1alpha protein (or SDF1alpha protein) is a recently discovered protein belonging to the alpha-chemokine (C-X-C) family of cytokines.
      Key Applications
      • Cell Culture
      Biological Information
      PurityGreater than 98% by SDS-PAGE and HPLC analysis
      SourceE.coli
      Specific ActivityBIOLOGICAL ACTIVITY: <br /><br />Determined by its ability to chemoattract human peripheral T cells activated with PHA and IL-2 using a concentration range of 20.0-80.0 ng/mL.
      Entrez Gene Number
      Entrez Gene SummaryFor background information on chemokines, see CXCL11 (SCYB11; MIM 604852). Stromal cell-derived factors 1-alpha and 1-beta are small cytokines that belong to the intercrine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF (see MIM 191160), or IL1 (see MIM 147760). The intercrines are characterized by the presence of 4 conserved cysteines which form 2 disulfide bonds. They can be classified into 2 subfamilies. In the CC subfamily, which includes beta chemokine, the cysteine residues are adjacent to each other. In the CXC subfamily, which includes alpha chemokine, they are separated by an intervening amino acid. The SDF1 proteins belong to the latter group.[supplied by OMIM]
      Gene Symbol
      • CXCL12
      • SDF1A
      • TLSF-b
      • TPAR1
      • SDF-1b
      • TLSF
      • SDF-1
      • SDF1
      • PBSF
      • TLSF-a
      • SDF1B
      • SCYB12
      • hIRH
      • SDF-1a
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P48061 # Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites.
      SIZE: 93 amino acids; 10666 Da
      SUBCELLULAR LOCATION: Secreted.
      PTM: Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processsed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.
      SIMILARITY: SwissProt: P48061 ## Belongs to the intercrine alpha (chemokine CxC) family.
      Stem Cell Type
      • Hematopoietic Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized powder, though stable at room temperature, is best stored desiccated below 0°C. Reconstitute in water to a concentration of 0.1-1 mg/mL. It is recommended that further dilutions be made into buffer containing carrier protein or medium containing serum. Reconstituted SDF1alpha should be stored at 4°C or in undiluted aliquots at -20°C for up to 6 months.
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Stromal Cell-Derived Factor-1α Protein, Recombinant human SDS

      Title

      Safety Data Sheet (SDS) 

      Stromal Cell-Derived Factor-1α Protein, Recombinant human Certificates of Analysis

      TitleLot Number
      RECOMBINANT HUMAN STROMAL CELL-DERIVED FACTOR-1 - 22013622201362
      RECOMBINANT HUMAN STROMAL CELL-DERIVED FACTOR-1 - 22876752287675
      RECOMBINANT HUMAN STROMAL CELL-DERIVED FACTOR-1 - 23157072315707
      RECOMBINANT HUMAN STROMAL CELL-DERIVED FACTOR-1#945; - 21350782135078
      RECOMBINANT HUMAN STROMAL CELL-DERIVED FACTOR-1α - 23874492387449

      Data Sheet

      Title
      RECOMBINANT HUMAN STROMAL CELL-DERIVED FACTOR-1alpha

      Related Products & Applications

      Product Families

      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors