GF021 Stem Cell Factor Protein, Recombinant human

GF021
10 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      SpeciesSourcePurity
      Human E.coli Greater than 98% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per μg (1EU/μg) of SCF.
      Description
      Catalogue NumberGF021
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionStem Cell Factor Protein, Recombinant human
      OverviewStem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultures and has been shown to act synergistically with colony stimulating factors. Recombinant human SCF is an 18.4 kDa protein containing 165 amino acid residues corresponding to the soluble secreted form of SCF.
      Alternate Names
      • SCF
      • Mast Cell Growth Factor
      • MGF
      • c-kit Ligand
      References
      Product Information
      PresentationThe sterile filtered solution was lyophilized from 10mM Acetic acid.
      Quality LevelMQ100
      Applications
      ApplicationThe Stem Cell Factor (SCF) Protein, Recombinant human, is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis.
      Application NotesFor most in vitro applications, SCF exerts its biological activity in the concentration range of 0.2 to 20.0 ng/mL. Responding cells are (partial list): Stem cells, BM precursor cells.
      Biological Information
      PurityGreater than 98% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per μg (1EU/μg) of SCF.
      SourceE.coli
      Specific ActivityChemicon's human SCF is fully biologically active when compared to standards. The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is <= 2 ng/mL, corresponding to a specific activity of >= 5 x 10e5 units/mg.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • KITLG
      • DKFZp686F2250
      • SCF
      • SF
      • MGF
      • Kitl
      • KL-1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P21583 # Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins.
      SIZE: 273 amino acids; 30899 Da
      SUBUNIT: Homodimer, non-covalently linked (Probable).
      SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein (By similarity). Note=Also exists as a secreted soluble form (isoform 1 only) (By similarity). & Isoform 2: Cell membrane; Single-pass type I membrane protein (By similarity).
      DEVELOPMENTAL STAGE: Acts in the early stages of hematopoiesis.
      PTM: A soluble form is produced by proteolytic processing of isoform 1 in the extracellular domain.
      SIMILARITY: SwissProt: P21583 ## Belongs to the SCF family.
      Stem Cell Type
      • Hematopoietic Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized powder, though stable for a few weeks at room temperature, is best stored at -20°C. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can be further diluted into other aqueous buffers and stored at 2-8°C for 1 week or -20°C for future use. Reconstituted SCF should be stored in undiluted aliquots at -20°C. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Stem Cell Factor Protein, Recombinant human SDS

      Title

      Safety Data Sheet (SDS) 

      Stem Cell Factor Protein, Recombinant human Certificates of Analysis

      TitleLot Number
      RECOMBINANT HUMAN STEM CELL FACTOR3050811
      RECOMBINANT HUMAN STEM CELL FACTOR3117787
      RECOMBINANT HUMAN STEM CELL FACTOR3066210
      RECOMBINANT HUMAN STEM CELL FACTOR2475586
      RECOMBINANT HUMAN STEM CELL FACTOR2914553
      RECOMBINANT HUMAN STEM CELL FACTOR3089586
      RECOMBINANT HUMAN STEM CELL FACTOR2952620
      RECOMBINANT HUMAN STEM CELL FACTOR3030265
      RECOMBINANT HUMAN STEM CELL FACTOR - 20128822012882
      RECOMBINANT HUMAN STEM CELL FACTOR - 20487622048762

      Related Products & Applications

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      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors