567731 Sphingosine Kinase Inhibitor - CAS 1177741-83-1 - Calbiochem

567731
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Key Specifications Table

Empirical FormulaCAS #
C₁₅H₁₁ClN₂OS • HCl 1177741-83-1

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567731-10MG
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      Plastic ampoule 10 mg
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      Description
      OverviewA cell-permeable disubstituted thiazole compound that displays anti-tumor properties. Acts as a potent, substrate competitive, reversible, and highly specific inhibitor of sphingosine kinase (IC50 = 0.5 µM for GST-hSK). Does not affect the kinase activity of hERK2, hPI3K, or PKCα even at concentrations as high as 60 µM. Induces apoptosis in human cancer cells that express the drug transport proteins Pgp or MRP1 (IC50 = ~ 1-5 µM) through inhibiting sphingosine-1-phosphate production.
      Catalogue Number567731
      Brand Family Calbiochem®
      Synonyms2-(p-Hydroxyanilino)-4-(p-chlorophenyl) thiazole, HCl, SK Inhibitor I
      References
      ReferencesFrench, K.J., et al. 2003. Cancer Res. 63, 5962.
      Product Information
      CAS number1177741-83-1
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₁₅H₁₁ClN₂OS • HCl
      Chemical formulaC₁₅H₁₁ClN₂OS • HCl
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGST-hsk
      Primary Target IC<sub>50</sub>0.5 µM for GST-hSK
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Sphingosine Kinase Inhibitor - CAS 1177741-83-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Sphingosine Kinase Inhibitor - CAS 1177741-83-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      567731

      References

      Reference overview
      French, K.J., et al. 2003. Cancer Res. 63, 5962.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms2-(p-Hydroxyanilino)-4-(p-chlorophenyl) thiazole, HCl, SK Inhibitor I
      DescriptionA cell-permeable, potent non-ATP-competitive, reversible, and specific inhibitor of sphingosine kinase (IC50 = 500 nM for GST-hSK) that also exhibits anti-tumor properties. Does not affect the kinase activity of hERK2, hPI3 K, or PKCα at cocentrations as high as 60 µM. Shown to induce apoptosis in human cancer cells that express the drug transport proteins Pgp or MRP1 (IC50 ~1-5 µM) by inhibiting sphingosine-1-phosphate production.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1177741-83-1
      Chemical formulaC₁₅H₁₁ClN₂OS • HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesFrench, K.J., et al. 2003. Cancer Res. 63, 5962.