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566405 Smad3 Inhibitor, SIS3 - CAS 1009104-85-1 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
1009104-85-1C₂₈H₂₇N₃O₃

Products

Catalog NumberPackaging Qty/Pack
566405-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable pyrrolopyridine compound that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling with no effect on Smad2, p38 MAPK, ERK, or PI 3-K signaling.
Catalogue Number566405
Brand Family Calbiochem®
Synonyms6,7-Dimethoxy-2-((2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-prop-2-enoyl))-1,2,3,4-tetrahydroisoquinoline, Specific Inhibitor of Smad3, SIS3
References
ReferencesJinnin, M., et al. 2006. Mol. Pharmacol. 69, 597.
Product Information
CAS number1009104-85-1
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₈H₂₇N₃O₃
Chemical formulaC₂₈H₂₇N₃O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetTGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
566405-1MG 04055977191516

Documentation

Smad3 Inhibitor, SIS3 - CAS 1009104-85-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Smad3 Inhibitor, SIS3 - CAS 1009104-85-1 - Calbiochem Certificates of Analysis

TitleLot Number
566405

References

Reference overview
Jinnin, M., et al. 2006. Mol. Pharmacol. 69, 597.

Brochure

Title
TGF-b Signaling: Dual Role in Tumor Suppression and Oncogenesis
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
Synonyms6,7-Dimethoxy-2-((2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-prop-2-enoyl))-1,2,3,4-tetrahydroisoquinoline, Specific Inhibitor of Smad3, SIS3
DescriptionA cell-permeable pyrrolopyridine compound that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling with no effect on Smad2, p38 MAPK, ERK, or PI 3-K signaling.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1009104-85-1
Chemical formulaC₂₈H₂₇N₃O₃
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (15 mg/ml) or Ethanol (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesJinnin, M., et al. 2006. Mol. Pharmacol. 69, 597.