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565725 SecinH3 - CAS 853625-60-2 - Calbiochem

565725
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Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₄H₂₀N₄O₄S 853625-60-2

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565725-5MG
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      Glass bottle 5 mg
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      Description
      OverviewA cell-permeable triazolo compound that acts as a Sec7 domain-binding (Kd ≤250 nM for Sec7 from human cytohesins 1-3), selective antagonist against cytohesin family small GEFs (IC50 ≤5.6 µM in ARF1 GDP/GTP exchange assays using human cytohesin 3, as well as murine and Drosophila homologues). It inhibits large GEFs only at much higher concentrations (IC50 ≥65 µM in GDP/GTP exchange assays using hEFA6-S7 and yGea2-S7) and exhibits little activity against a panel of 10 commonly studied kinases or hSosII. Shown to effectively inhibit insulin signaling both in HepG2 cells in vitro and in Drosophila and mice in vivo.
      Catalogue Number565725
      Brand Family Calbiochem®
      SynonymsN-(4-(5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl)phenyl)-2-(phenylthio)acetamide, Cytohesin Inhibitor I
      References
      ReferencesHafner, M., et al. 2006. Nature 444, 941.
      Fuss, B., et al. 2006. Nature 444, 945.
      Product Information
      CAS number853625-60-2
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₄H₂₀N₄O₄S
      Chemical formulaC₂₄H₂₀N₄O₄S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCytohesin
      Primary Target IC<sub>50</sub>Kd ≤250 nM for Sec7 from human cytohesins 1-3; IC50 ≤5.6 µM in ARF1 GDP/GTP exchange assays using human cytohesin 3, as well as murine and Drosophila homologues
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SecinH3 - CAS 853625-60-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      SecinH3 - CAS 853625-60-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      565725

      References

      Reference overview
      Hafner, M., et al. 2006. Nature 444, 941.
      Fuss, B., et al. 2006. Nature 444, 945.

      Brochure

      Title
      Biologics 33.2
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-August-2007 JSW
      SynonymsN-(4-(5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl)phenyl)-2-(phenylthio)acetamide, Cytohesin Inhibitor I
      DescriptionA cell-permeable triazolo compound that acts as a Sec7 domain-binding (Kd ≤250 nM for Sec7 from human cytohesins 1-3), selective antagonist against cytohesin family small GEFs (IC50 ≤5.6 µM in ARF1 GDP/GTP exchange assays using human cytohesin 3, as well as murine and Drosophila homologues). It inhibits large GEFs only at much higher concentrations (IC50 ≥65 µM in GDP/GTP exchange assays using hEFA6-S7 and yGea2-S7) and exhibits little activity against a panel of 10 commonly studied kinases or hSosII. Shown to effectively inhibit insulin signaling both in HepG2 cells in vitro and in Drosophila and mice in vivo.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number853625-60-2
      Chemical formulaC₂₄H₂₀N₄O₄S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesHafner, M., et al. 2006. Nature 444, 941.
      Fuss, B., et al. 2006. Nature 444, 945.