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572632 SU5614 - CAS 186611-56-3 - Calbiochem

572632
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Key Specifications Table

Empirical FormulaCAS #
C₁₅H₁₃N₂OCl 186611-56-3

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572632-1MG
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      Description
      OverviewA potent, cell-permeable, reversible, ATP-competitive, and selective inhibitor of VEGF (Flk-1; IC50 = 1.2 µM) and PDGF (IC50 = 2.9 µM) receptor tyrosine kinases. Does not have any effect on the EGF and IGF receptor tyrosine kinases. Also inhibits the VEGF-driven mitogenesis of human umbilical vein endothelial cells (HUVECs; IC50 ≤ 680 nM). Inhibits Flt3 phosphorylation in Flt3/Itd-BaF3 cells.
      Catalogue Number572632
      Brand Family Calbiochem®
      Synonyms5-Chloro-3-[(3,5-dimethylpyrrol-2-yl)methylene]-2-indolinone, VEGFR Tyrosine Kinase Inhibitor VII, VEGFR2 Kinase Inhibitor IX
      References
      ReferencesCools, J., et al. 2004. Cancer Res. 64, 6385.
      Sun, L., et al. 1998. J. Med. Chem. 41, 2588.
      Product Information
      CAS number186611-56-3
      ATP CompetitiveY
      DeclarationNot available for sale in the United States.
      FormOrange-red solid
      Hill FormulaC₁₅H₁₃N₂OCl
      Chemical formulaC₁₅H₁₃N₂OCl
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetVEGF Flk-1
      Primary Target IC<sub>50</sub>1.2 µM, 2.9 µM against VEGF (Flk-1) and PDGF receptor tyrosine kinases, respectively; ≤680 nM against the VEGF-driven mitogenesis of human umbilical vein endothelial cells (HUVECs)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SU5614 - CAS 186611-56-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      SU5614 - CAS 186611-56-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      572632

      References

      Reference overview
      Cools, J., et al. 2004. Cancer Res. 64, 6385.
      Sun, L., et al. 1998. J. Med. Chem. 41, 2588.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms5-Chloro-3-[(3,5-dimethylpyrrol-2-yl)methylene]-2-indolinone, VEGFR Tyrosine Kinase Inhibitor VII, VEGFR2 Kinase Inhibitor IX
      DescriptionA potent, cell-permeable, reversible, ATP-competitive, and selective inhibitor of VEGF (Flk-1; IC50 = 1.2 µM) and PDGF (IC50 = 2.9 µM) receptor tyrosine kinases. Does not have any effect on the EGF and IGF receptor tyrosine kinases. Also inhibits the VEGF-driven mitogenesis of human umbilical vein endothelial cells (HUVECs; IC50 ≤680 nM). Inhibits Flt3 phosphorylation in Flt3/Itd-BaF3 cells.
      FormOrange-red solid
      CAS number186611-56-3
      Chemical formulaC₁₅H₁₃N₂OCl
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Standard Handling
      ReferencesCools, J., et al. 2004. Cancer Res. 64, 6385.
      Sun, L., et al. 1998. J. Med. Chem. 41, 2588.