573102 STAT3 Inhibitor VI, S3I-201 - CAS 501919-59-1 - Calbiochem

573102
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₆H₁₅NO₇S 501919-59-1

Pricing & Availability

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573102-10MG
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      Plastic ampoule 10 mg
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      573102-25MG
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          Description
          OverviewA cell-permeable amidosalicylic acid compound that binds Stat3-SH2 domain and prevents Stat3 phosphorylation/activation, dimerization, DNA-binding, and Stat3-dependent transcription. Shown to arrest Stat3-dependent tumor growth both in cultures in vitro (effective conc. ≤100 µM) and in a murine xenograft model in vivo (5 mg/kg, i.v.). Also available as a 50 mM solution in DMSO (Cat. No. 573130).
          Catalogue Number573102
          Brand Family Calbiochem®
          Synonyms2-Hydroxy-4-(((4-methylphenyl)sulfonyloxy)acetyl)amino)-benzoic acid, NSC 74859
          References
          ReferencesLin, L., et al. 2009. Oncogene, 28, 961.
          Siddiquee, K., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7391.
          Product Information
          CAS number501919-59-1
          FormLight beige solid
          Hill FormulaC₁₆H₁₅NO₇S
          Chemical formulaC₁₆H₁₅NO₇S
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Regulatory Review
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          STAT3 Inhibitor VI, S3I-201 - CAS 501919-59-1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          STAT3 Inhibitor VI, S3I-201 - CAS 501919-59-1 - Calbiochem Certificates of Analysis

          TitleLot Number
          573102

          References

          Reference overview
          Lin, L., et al. 2009. Oncogene, 28, 961.
          Siddiquee, K., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7391.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-March-2009 RFH
          Synonyms2-Hydroxy-4-(((4-methylphenyl)sulfonyloxy)acetyl)amino)-benzoic acid, NSC 74859
          DescriptionA cell-permeable amidosalicylic acid compound that binds Stat3-SH2 domain and prevents Stat3 phosphorylation/activation, dimerization, DNA-binding, and Stat3-dependent transcription. Shown to arrest Stat3-dependent tumor growth both in cultures in vitro (effective conc. ≤100 µM) and in a murine xenograft model in vivo (5 mg/kg, i.v.).
          FormLight beige solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number501919-59-1
          Chemical formulaC₁₆H₁₅NO₇S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml). Use only fresh, anhydrous DMSO.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Regulatory Review
          ReferencesLin, L., et al. 2009. Oncogene, 28, 961.
          Siddiquee, K., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7391.