567693 SOST, Mouse, Recombinant

567693
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Overview

Replacement Information

Key Specifications Table

Purity
≥90% by SDS-PAGE

Pricing & Availability

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567693-25UG
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      Glass bottle 25 μg
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      Description
      OverviewRecombinant, mouse sclerostin (SOST) consisting of amino acids 24-211, expressed in NS0-derived murine myeloma cells with an N-terminal His•Tag®. SOST is expressed by osteoclasts in developing bones of mouse embryos and acts as a negative regulator of bone formation through repression of BMP-induced osteogenesis.
      Catalogue Number567693
      Brand Family Calbiochem®
      References
      ReferencesKusu, N. et al. 2003. J. Biol. Chem. 278, 24113.
      Balemans, W. et al. 2001. Hum. Mol. Genet. 10 537.
      Brunkow, M.E. et al. 2001. Am. J. Hum. Genet. 68, 577.
      Product Information
      FormSolid
      FormulationLyophilized from 0.2 µm filter-sterilized PBS, BSA.
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityInhibition Assay: Inhibits hBMP-6-induced alkaline phosphatase by 50-80% in MC3T3-E1 mouse osteoblastic cells when used at a concentration of 30 µg/ml.
      Purity≥90% by SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: <1.0 EU/µg protein
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SOST, Mouse, Recombinant SDS

      Title

      Safety Data Sheet (SDS) 

      SOST, Mouse, Recombinant Certificates of Analysis

      TitleLot Number
      567693

      References

      Reference overview
      Kusu, N. et al. 2003. J. Biol. Chem. 278, 24113.
      Balemans, W. et al. 2001. Hum. Mol. Genet. 10 537.
      Brunkow, M.E. et al. 2001. Am. J. Hum. Genet. 68, 577.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-Sepmtember-2011 RFH
      DescriptionRecombinant, mouse sclerostin (SOST) consisting of amino acids 24-211, expressed in NS0-derived murine myeloma cells with an N-terminal His•Tag®. SOST is expressed by osteoclasts in developing bones of mouse embryos and acts as a negative regulator of bone formation through repression of BMP-induced osteogenesis.
      FormSolid
      FormulationLyophilized from 0.2 µm filter-sterilized PBS, BSA.
      Purity≥90% by SDS-PAGE
      ContaminantsEndotoxin: <1.0 EU/µg protein
      Biological activityInhibition Assay: Inhibits hBMP-6-induced alkaline phosphatase by 50-80% in MC3T3-E1 mouse osteoblastic cells when used at a concentration of 30 µg/ml.
      SolubilityReconstitute to 200 µg/ml in sterile PBS containing at least 0.1% human or bovine serum albumin.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKusu, N. et al. 2003. J. Biol. Chem. 278, 24113.
      Balemans, W. et al. 2001. Hum. Mol. Genet. 10 537.
      Brunkow, M.E. et al. 2001. Am. J. Hum. Genet. 68, 577.