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573115 SMCC, Water-Soluble

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573115
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Overview

Replacement Information

Key Specifications Table

CAS #Purity
92921-24-9≥94% by HPLC

Products

Catalog NumberPackaging Qty/Pack
573115-50MG Plastic ampoule 50 mg
Description
OverviewIdeal for coupling enzymes to antibodies. Contains a cyclohexane bridge, which gives extra stability to the maleimide group. Both enzyme activity and antibody specificity are preserved after coupling.
Catalogue Number573115
Brand Family Calbiochem®
SynonymsSulfosuccinimidyl-trans-4-(N-maleimidomethyl)cyclohexane-1-carboxylate, Sulfo-SMCC
References
ReferencesD’Souza, S.E., et al. 1988. J. Biol. Chem. 263, 3943.
Product Information
CAS number92921-24-9
FormOff-white solid
Hill FormulaC₁₆H₁₇N₂O₉S · Na
Chemical formulaC₁₆H₁₇N₂O₉S · Na
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥94% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing each use, purge the original vial with inert gas and refrigerate (4°C). Unstable in aqueous solution; reconstitute just prior to use. Alternatively, the solid SMCC can be added directly to the sample to minimize hydrolysis. Hydrolysis is more pronounced in dilute protein solutions and can, therefore, be minimized by using more concentrated protein solutions (>5 mg/ml). For storage of stock solutions, reconstitute in anhydrous DMSO.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

SMCC, Water-Soluble SDS

Title

Safety Data Sheet (SDS) 

SMCC, Water-Soluble Certificates of Analysis

TitleLot Number
573115

References

Reference overview
D’Souza, S.E., et al. 1988. J. Biol. Chem. 263, 3943.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-September-2008 RFH
SynonymsSulfosuccinimidyl-trans-4-(N-maleimidomethyl)cyclohexane-1-carboxylate, Sulfo-SMCC
DescriptionA water-soluble derivative of SMCC. Ideal for coupling enzymes to antibodies. Contains a cyclohexane bridge, which gives extra stability to the maleimide group. Both enzyme activity and antibody specificity are preserved after coupling. Water-soluble cross-linking reagents help to avoid the use of organic solvents such as dimethylformamide (DMF) and dimethylsulfoxide (DMSO) when preparing bioconjugates.
FormOff-white solid
CAS number92921-24-9
Chemical formulaC₁₆H₁₇N₂O₉S · Na
Structure formulaStructure formula
Purity≥94% by HPLC
SolubilityH₂O (2-5 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing each use, purge the original vial with inert gas and refrigerate (4°C). Unstable in aqueous solution; reconstitute just prior to use. Alternatively, the solid SMCC can be added directly to the sample to minimize hydrolysis. Hydrolysis is more pronounced in dilute protein solutions and can, therefore, be minimized by using more concentrated protein solutions (>5 mg/ml). For storage of stock solutions, reconstitute in anhydrous DMSO.
Toxicity Irritant
ReferencesD’Souza, S.E., et al. 1988. J. Biol. Chem. 263, 3943.