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508149 SB 699551 Dihydrochloride - CAS 791789-61-2 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-HT5A Serotonin Receptor Antagonist, SB 699551, SB 699551, SB699551, SB-699551

Primary Target: 5-HT5A
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
791789-61-2C₃₄H₄₅N₃O·2HCl
Description
OverviewA selective, brain penetrant, 5-HT5A receptor antagonis (pKi = 8.2). Competitively antagonised 5-HT-stimulated [35S]GTPγS binding to membranes from human embryonic kidney (HEK293) cells transiently expressing the guinea pig 5-HT5A receptor (pA2 8.1 ± 0.1) and displayed 100-fold selectivity versus the serotonin transporter and those 5-HT receptor subtypes (5-HT1A/B/D, 5-HT2A/C and 5-5-HT7).
Catalogue Number508149
Brand Family Calbiochem®
Synonyms5-HT5A Serotonin Receptor Antagonist, SB 699551, SB 699551, SB699551, SB-699551
References
ReferencesFerenc, K. et al. 2012. Behav. Pharmacol. 23, 397.
Thomas, D. R. et al. 2006. Neuropharmacol. 51, 566.
Corbett, D. F. et al. 2005. Bioorg. Med. Chem. Lett. 15, 4014.
Product Information
CAS number791789-61-2
FormWhite solid
Hill FormulaC₃₄H₄₅N₃O·2HCl
Chemical formulaC₃₄H₄₅N₃O·2HCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target5-HT5A
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Catalog Number GTIN
508149

Documentation

SB 699551 Dihydrochloride - CAS 791789-61-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Ferenc, K. et al. 2012. Behav. Pharmacol. 23, 397.
Thomas, D. R. et al. 2006. Neuropharmacol. 51, 566.
Corbett, D. F. et al. 2005. Bioorg. Med. Chem. Lett. 15, 4014.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-October-2013 JSW
Synonyms5-HT5A Serotonin Receptor Antagonist, SB 699551, SB 699551, SB699551, SB-699551
DescriptionA selective, brain penetrant, 5-HT5A receptor antagonis (pKi = 8.2). Competitively antagonised 5-HT-stimulated [35S]GTPγS binding to membranes from human embryonic kidney (HEK293) cells transiently expressing the guinea pig 5-HT5A receptor (pA2 8.1 ± 0.1) and displayed 100-fold selectivity versus the serotonin transporter and those 5-HT receptor subtypes (5-HT1A/B/D, 5-HT2A/C and 5-5-HT7).
FormWhite solid
CAS number791789-61-2
Chemical formulaC₃₄H₄₅N₃O·2HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (25 mM) or Ethanol (10 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesFerenc, K. et al. 2012. Behav. Pharmacol. 23, 397.
Thomas, D. R. et al. 2006. Neuropharmacol. 51, 566.
Corbett, D. F. et al. 2005. Bioorg. Med. Chem. Lett. 15, 4014.