Our broad portfolio consists of multiplex panels that allow you to choose, within the panel, analytes that best meet your needs. On a separate tab you can choose the premixed cytokine format or a single plex kit.
Cell Signaling Kits & MAPmates™
Choose fixed kits that allow you to explore entire pathways or processes. Or design your own kits by choosing single plex MAPmates™, following the provided guidelines.
The following MAPmates™ should not be plexed together:
-MAPmates™ that require a different assay buffer
-Phospho-specific and total MAPmate™ pairs, e.g. total GSK3β and GSK3β (Ser 9)
-PanTyr and site-specific MAPmates™, e.g. Phospho-EGF Receptor and phospho-STAT1 (Tyr701)
-More than 1 phospho-MAPmate™ for a single target (Akt, STAT3)
-GAPDH and β-Tubulin cannot be plexed with kits or MAPmates™ containing panTyr
.
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To begin designing your MILLIPLEX® MAP kit select a species, a panel type or kit of interest.
Custom Premix Selecting "Custom Premix" option means that all of the beads you have chosen will be premixed in manufacturing before the kit is sent to you.
If you have chosen panel analytes and then choose a premix or single plex kit, you will lose that customization.
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Add Additional Reagents (Buffer and Detection Kit is required for use with MAPmates)
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48-602MAG
Buffer Detection Kit for Magnetic Beads
1 Kit
Space Saver Option Customers purchasing multiple kits may choose to save storage space by eliminating the kit packaging and receiving their multiplex assay components in plastic bags for more compact storage.
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508119
Sigma-AldrichSB 399885 Hydrochloride - CAS 402713-80-8 - Calbiochem
A high affinity 5-HT6 Receptor antagonist (pKi = 9.0). Good solubility (to 100 mM in water or DMSO), oral availability, and penetrant to blood brain barrier. Over 200-fold selective for 5-HT6 receptors vs all receptors, ion channels and enzymes tested in Hirst et al. 2006 publication. Shows nootropic, antidepressant and axiolytic effects comparable to well-described drugs such as diazepam, and therefore has been proposed as novel treatment for schizoprenia and Alzheimer′s disease.
Wesolowska, A. et al. 2007. Pharmacol Rep.59, 664. Li, Z. et al. 2007. Brain Res.1134, 70. Hirst, et al. 2006. Eur. J. Pharm.553, 109. Routledge, C. et al. 2000. Br. J. Pharmacol.130, 1606.
Wesolowska, A. et al. 2007. Pharmacol Rep.59, 664. Li, Z. et al. 2007. Brain Res.1134, 70. Hirst, et al. 2006. Eur. J. Pharm.553, 109. Routledge, C. et al. 2000. Br. J. Pharmacol.130, 1606.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A high affinity 5-HT6 Receptor antagonist (pKi = 9.0). Good solubility (to 100 mM in water or DMSO), oral availability, and penetrant to blood brain barrier. Over 200-fold selective for 5-HT6 receptors vs all receptors, ion channels and enzymes tested in Hirst et al. 2006 publication. Shows nootropic, antidepressant and axiolytic effects comparable to well-described drugs such as diazepam, and therefore has been proposed as novel treatment for schizoprenia and Alzheimer′s disease.
Form
White solid
CAS number
402713-80-8
Chemical formula
C₁₈H₂₁Cl₂N₃O₄S·HCl
Structure formula
Purity
≥99% by HPLC
Solubility
DMSO (100 mM) or H₂O (100 mM)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Wesolowska, A. et al. 2007. Pharmacol Rep.59, 664. Li, Z. et al. 2007. Brain Res.1134, 70. Hirst, et al. 2006. Eur. J. Pharm.553, 109. Routledge, C. et al. 2000. Br. J. Pharmacol.130, 1606.
