The quantity field is empty. Please enter a quantity of 1 or more to add items to your cart.
Description
Overview
A brain-penetrant, high-affinity, and selective dopamine D3 receptor antagonist. High affinity for the hD3 receptor (pKi = 7.95) with 100-fold selectivity over the hD2 receptor and over 66 other receptors, enzymes, and ion channels. Rat data shows that the compound is selective for the D3 receptor over certain serotonergic and cholinergic receptors at doses up to 56.0 mg/kg and strong physiological response at 32.0 mg/kg.
Collins, G. T. et al. 2005. J. Pharmacol. Exp. Ther.314, 310. Reavill, C. et al. 2000. J. Pharmacol. Exp. Ther.294, 1154.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A brain-penetrant, high-affinity, and selective dopamine D3 receptor antagonist. High affinity for the hD3 receptor (pKi = 7.95) with 100-fold selectivity over the hD2 receptor and over 66 other receptors, enzymes, and ion channels. Rat data shows that the compound is selective for the D3 receptor over certain serotonergic and cholinergic receptors at doses up to 56.0 mg/kg and strong physiological response at 32.0 mg/kg.
Form
White solid
CAS number
1226917-67-4
Chemical formula
C₂₈H₃₀N₄O•2HCl
Structure formula
Purity
≥98% by HPLC
Solubility
H₂O (100 mM)
Storage
Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Collins, G. T. et al. 2005. J. Pharmacol. Exp. Ther.314, 310. Reavill, C. et al. 2000. J. Pharmacol. Exp. Ther.294, 1154.