Our broad portfolio consists of multiplex panels that allow you to choose, within the panel, analytes that best meet your needs. On a separate tab you can choose the premixed cytokine format or a single plex kit.
Cell Signaling Kits & MAPmates™
Choose fixed kits that allow you to explore entire pathways or processes. Or design your own kits by choosing single plex MAPmates™, following the provided guidelines.
The following MAPmates™ should not be plexed together:
-MAPmates™ that require a different assay buffer
-Phospho-specific and total MAPmate™ pairs, e.g. total GSK3β and GSK3β (Ser 9)
-PanTyr and site-specific MAPmates™, e.g. Phospho-EGF Receptor and phospho-STAT1 (Tyr701)
-More than 1 phospho-MAPmate™ for a single target (Akt, STAT3)
-GAPDH and β-Tubulin cannot be plexed with kits or MAPmates™ containing panTyr
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To begin designing your MILLIPLEX® MAP kit select a species, a panel type or kit of interest.
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48-602MAG
Buffer Detection Kit for Magnetic Beads
1 Kit
Space Saver Option Customers purchasing multiple kits may choose to save storage space by eliminating the kit packaging and receiving their multiplex assay components in plastic bags for more compact storage.
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506417
Sigma-AldrichSB 242084 Hydrochloride - CAS 181632-25-7 - Calbiochem
A selective, brain-penetrant 5-HT2C receptor antagonist (pKi 8.2-9.0 ), with some effects on the 5-HT2B receptor (pKi 6.8-7.0) and 5-HT2A receptor (pKi 6.1-6.8). SB 242084 has been shown to increase the effectiveness of the selective serotonin reuptake inhibitor (SSRI) class of antidepressants, and may also reduce their side effects. In animal studies, SB-242,084 produced stimulant-type activity and reinforcing effects, somewhat similar to but much weaker than cocaine or amphetamines. In vivo (ocular) IC50 values reported at 2.08 µM.
Manvich, D. F., et al. 2012. J Pharmacol. Exp. Ther.342, 761. Burghardt, N. S., et al. 2007. Biol Psychiatry62, 1111. Sharif, N. A., et al. 2007. J. Ocul. Pharmacol. Ther.23, 1. Knight A. R., et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114. Kennett G.A., et al. 1997. Neuropharmacol. 36, 609.
Manvich, D. F., et al. 2012. J Pharmacol. Exp. Ther.342, 761. Burghardt, N. S., et al. 2007. Biol Psychiatry62, 1111. Sharif, N. A., et al. 2007. J. Ocul. Pharmacol. Ther.23, 1. Knight A. R., et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114. Kennett G.A., et al. 1997. Neuropharmacol. 36, 609.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A selective, brain-penetrant 5-HT2C receptor antagonist (pKi 8.2-9.0 ), with some effects on the 5-HT2B receptor (pKi 6.8-7.0) and 5-HT2A receptor (pKi 6.1-6.8). SB 242084 has been shown to increase the effectiveness of the selective serotonin reuptake inhibitor (SSRI) class of antidepressants, and may also reduce their side effects. In animal studies, SB-242,084 produced stimulant-type activity and reinforcing effects, somewhat similar to but much weaker than cocaine or amphetamines. In vivo (ocular) IC50 values reported at 2.08 µM.
Form
Off-white to pale yellow solid
CAS number
181632-25-7
Chemical formula
C₂₁H₁₉ClN₄O₂·HCl
Structure formula
Purity
≥98% by HPLC
Solubility
DMSO (50 mM) or H₂O (50 mM)
Storage
Protect from light
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Manvich, D. F., et al. 2012. J Pharmacol. Exp. Ther.342, 761. Burghardt, N. S., et al. 2007. Biol Psychiatry62, 1111. Sharif, N. A., et al. 2007. J. Ocul. Pharmacol. Ther.23, 1. Knight A. R., et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114. Kennett G.A., et al. 1997. Neuropharmacol. 36, 609.
