559396 SB 220025

559396
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₈H₁₉FN₆ 165806-53-1

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559396-500UG
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      Plastic ampoule 500 μg
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      Description
      OverviewA cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC50 = 60 nM). Binds to an extended pocket in the active site of the enzyme. Exhibits over 2000-fold greater selectivity for p38 MAPK over ERK (p42/p44 MAP kinase), 500-fold over PKA, 50-fold over PKC, and >1000-fold over EGFR. Also acts as a potent inhibitor of angiogenesis and as an inhibitor of LPS-induced TNF-α production.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number559396
      Brand Family Calbiochem®
      Synonyms5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole, p38 MAP Kinase Inhibitor XIV
      References
      ReferencesJackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther. 284, 687.
      Wang, Z., et al. 1998. Structure 6, 1117.
      Product Information
      CAS number165806-53-1
      FormWhite to pale yellow solid
      Hill FormulaC₁₈H₁₉FN₆
      Chemical formulaC₁₈H₁₉FN₆
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetP38MAPK
      Primary Target IC<sub>50</sub>60 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SB 220025 SDS

      Title

      Safety Data Sheet (SDS) 

      SB 220025 Certificates of Analysis

      TitleLot Number
      559396

      References

      Reference overview
      Jackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther. 284, 687.
      Wang, Z., et al. 1998. Structure 6, 1117.

      Brochure

      Title
      MAPK Pathway Poster ( 750 KB )
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-November-2014 JSW
      Synonyms5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole, p38 MAP Kinase Inhibitor XIV
      DescriptionA potent and specific inhibitor of human p38 mitogen-activated protein (MAP) kinase (IC50 = 60 nM). Binds to an extended pocket in the active site of the enzyme. Exhibits >2500-fold greater selectivity for p38 MAPK over ERK (p42/p44 MAP kinase), 500-fold over PKA, 50-fold over PKC, and >1600-fold over EGFRK. Also acts as a potent inhibitor of angiogenesis and as an inhibitor of LPS-induced TNF-α production.
      FormWhite to pale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number165806-53-1
      Chemical formulaC₁₈H₁₉FN₆
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (22 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesJackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther. 284, 687.
      Wang, Z., et al. 1998. Structure 6, 1117.

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > MAP Kinase Inhibitors