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557550 Ro106-9920

A cell-permeable tetrazolopyridazine-phenylsulfoxide compound that displays anti-inflammatory properties.

Ro106-9920 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: IκBαee ubiquitination
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557550
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
62645-28-7C₁₀H₇N₅OS

Products

Catalog NumberPackaging Qty/Pack
557550-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable tetrazolopyridazine-phenylsulfoxide compound that displays anti-inflammatory properties. Acts as a highly selective, irreversible inhibitor of IκBαee ubiquitination (IC50 = 2.3 µM). Blocks NF-κB-dependent cytokine expression in human PBMNs (IC50’s = ~ 700 nM for TNF-α, IL-1β, and IL-6 inhibition) and rats. Does not inhibit SCFβTRCP(IκBα ubiquitin ligase)-mediated β-catenin ubiquitination in Jurkat cells. At 10 µM concentrations, also inhibits the activities of 5-lipoxygenase (by 89%) and EGFR kinase (by 63%).
Catalogue Number557550
Brand Family Calbiochem®
References
ReferencesSwinney, D.C., et al. 2002. J. Biol. Chem. 277, 23573.
Product Information
CAS number62645-28-7
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₀H₇N₅OS
Chemical formulaC₁₀H₇N₅OS
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetIκBαee ubiquitination
Primary Target IC<sub>50</sub>2.3 µM against IκBαee ubiquitination
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
557550-1MG 04055977193015

Documentation

Ro106-9920 SDS

Title

Safety Data Sheet (SDS) 

Ro106-9920 Certificates of Analysis

TitleLot Number
557550

References

Reference overview
Swinney, D.C., et al. 2002. J. Biol. Chem. 277, 23573.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-April-2009 JSW
DescriptionA cell-permeable tetrazolopyridazine-phenylsulfoxide compound that displays anti-inflammatory properties. Acts as a highly selective, irreversible inhibitor of IκBαee ubiquitination (IC50 = 2.3 µM). Also reported to prevent degradation of IκBαee in MM6 cells (complete inhibition at ~3-5 µM). Shown to block NF-κB-dependent cytokine expression in human peripheral blood mononuclear cells (PBMN) (IC50 = 600-700 nM for TNF-α, IL-1β, and IL-6 inhibition). Also shown to lower circulating levels of TNFα in LPS-treated rats. Also shown to inhibit 5-lipoxygenase (89% inhibition) and EGFR kinase (63% inhibition) at higher concentrations (10 µM).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number62645-28-7
Chemical formulaC₁₀H₇N₅OS
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (25 mg/ml) or Ethanol (1 mg/ml)
Storage Protect from moisture
Protect from light
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
Toxicity Standard Handling
ReferencesSwinney, D.C., et al. 2002. J. Biol. Chem. 277, 23573.