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557525 Ro-32-0432 - CAS 145333-02-4 - Calbiochem

557525
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Key Specifications Table

Empirical FormulaCAS #
C₂₈H₂₈N₄O₂ · HCl 145333-02-4

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557525-1MG
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      Description
      OverviewA selective cell-permeable protein kinase C inhibitor. Displays about 10-fold greater selectivity for PKCα (IC50 = 9 nM) and 4-fold greater selectivity for PKCβI (IC50 = 28 nM) over PKCε (IC50 = 108 nM). Also prevents T cell-driven chronic inflammatory responses in vivo.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number557525
      Brand Family Calbiochem®
      Synonyms2-{8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl}-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide XI, HCl, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-y1)-4-(1-methyl-1H-indol-3-y1)-1H-pyrrole-2,5-dione hydrochloride
      References
      ReferencesBirchall, A.M., et al. 1994. J. Pharmacol. Exp. Ther. 268, 922.
      Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
      Product Information
      CAS number145333-02-4
      ATP CompetitiveN
      FormRed solid
      Hill FormulaC₂₈H₂₈N₄O₂ · HCl
      Chemical formulaC₂₈H₂₈N₄O₂ · HCl
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKCα
      Primary Target IC<sub>50</sub>9 nM, 28 nM, 108 nM, against PKCα, PKCβI, and PKCε, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ro-32-0432 - CAS 145333-02-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Ro-32-0432 - CAS 145333-02-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      557525

      References

      Reference overview
      Birchall, A.M., et al. 1994. J. Pharmacol. Exp. Ther. 268, 922.
      Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.

      Brochure

      Title
      PKC Pathway Poster PDF ( 676 KB )

      Citations

      Title
    • Felicity J. Ashcroft, et al. (2004) Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element. Biochemical Journal 381, 397-403.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-October-2014 JSW
      Synonyms2-{8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl}-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide XI, HCl, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-y1)-4-(1-methyl-1H-indol-3-y1)-1H-pyrrole-2,5-dione hydrochloride
      DescriptionA selective cell-permeable protein kinase C inhibitor. Displays about a 10-fold greater selectivity for PKCα (IC50 = 9 nM) and a 4-fold greater selectivity for PKCβI (IC50 = 28 nM) over PKCε (IC50 = 108 nM). Also prevents T-cell driven chronic inflammatory responses in vivo.
      FormRed solid
      CAS number145333-02-4
      Chemical formulaC₂₈H₂₈N₄O₂ · HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Toxicity Standard Handling
      ReferencesBirchall, A.M., et al. 1994. J. Pharmacol. Exp. Ther. 268, 922.
      Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
      Citation
    • Felicity J. Ashcroft, et al. (2004) Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element. Biochemical Journal 381, 397-403.