Millipore Sigma Vibrant Logo

504845 Ro 25-6981 Maleate Salt - CAS 169274-78-6 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: [R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate

Primary Target: GluN1/NR2B receptors
View Products on Sigmaaldrich.com
504845
  
Retrieving price...
Price could not be retrieved
Minimum Quantity is a multiple of
Maximum Quantity is
Upon Order Completion More Information
You Saved ()
 
—
Request Pricing
—
Fulfilment and delivery delayed Fulfilment and delivery delayed
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

       

      Contact Customer Service

      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      169274-78-6C₂₂H₂₉NO₂•C₄H₄O₄
      Description
      OverviewA potent, activity-dependent antagonist highly selective for GluN1/NR2B subtype NMDA receptors (IC50 = 0.009 and 52 µM for NR2B and NR2A subtype receptors respectively). Commonly used for studying brain functions and disorders involving neurotransmissions mediated by GluN1/NR2B subtype NMDA receptors (learning and memory, neuroplasticity, neurotoxicity, neuropathic pain, addiction, and neurogenesis enhancement).
      Catalogue Number504845
      Brand Family Calbiochem®
      Synonyms[R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate
      References
      ReferencesQi, Y., et al. 2013. Cereb. Cortex. 23, 932.
      Soloviova, A., et al. 2012. Exp. Biol. & Med. 153, 764.
      Solovyeva, A., et al. 2012. Neurosci. & Behav. Physiol. 42, 456.
      Chazot, L., et al. 2004. Curr. Med. Chem. 11, 389.
      Lynch, R., et al. 2001. Eur. J. Pharmacol. 416, 185.
      Fischer, G., et al. 1997. J. Pharmacol. Exp. Ther. 283, 1285.
      Product Information
      CAS number169274-78-6
      FormWhite solid
      Hill FormulaC₂₂H₂₉NO₂•C₄H₄O₄
      Chemical formulaC₂₂H₂₉NO₂•C₄H₄O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGluN1/NR2B receptors
      Primary Target IC<sub>50</sub>0.009 →M
      Purity≥99% by Chiral HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ro 25-6981 Maleate Salt - CAS 169274-78-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Qi, Y., et al. 2013. Cereb. Cortex. 23, 932.
      Soloviova, A., et al. 2012. Exp. Biol. & Med. 153, 764.
      Solovyeva, A., et al. 2012. Neurosci. & Behav. Physiol. 42, 456.
      Chazot, L., et al. 2004. Curr. Med. Chem. 11, 389.
      Lynch, R., et al. 2001. Eur. J. Pharmacol. 416, 185.
      Fischer, G., et al. 1997. J. Pharmacol. Exp. Ther. 283, 1285.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-July-2013 JSW
      Synonyms[R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate
      DescriptionA potent, activity-dependent antagonist highly selective for GluN1/NR2B subtype NMDA receptors (IC50 = 0.009 and 52 µM for NR2B and NR2A subtype receptors respectively). Commonly used for studying brain functions and disorders involving neurotransmissions mediated by GluN1/NR2B subtype NMDA receptors (learning and memory, neuroplasticity, neurotoxicity, neuropathic pain, addiction, and neurogenesis enhancement).
      FormWhite solid
      CAS number169274-78-6
      Chemical formulaC₂₂H₂₉NO₂•C₄H₄O₄
      Structure formulaStructure formula
      Purity≥99% by Chiral HPLC
      SolubilityH₂O (25 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesQi, Y., et al. 2013. Cereb. Cortex. 23, 932.
      Soloviova, A., et al. 2012. Exp. Biol. & Med. 153, 764.
      Solovyeva, A., et al. 2012. Neurosci. & Behav. Physiol. 42, 456.
      Chazot, L., et al. 2004. Curr. Med. Chem. 11, 389.
      Lynch, R., et al. 2001. Eur. J. Pharmacol. 416, 185.
      Fischer, G., et al. 1997. J. Pharmacol. Exp. Ther. 283, 1285.