480150 Sigma-AldrichRas-Net (Elk-3) Pathway Inhibitor, XRP44X - CAS 729605-21-4 - Calbiochem
The Ras-Net (Elk-3) Pathway Inhibitor, XRP44X, also referenced under CAS 729605-21-4, controls the biological activity of Ras-Net (Elk-3).
More>> The Ras-Net (Elk-3) Pathway Inhibitor, XRP44X, also referenced under CAS 729605-21-4, controls the biological activity of Ras-Net (Elk-3). Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 1-(3-Chlorophenyl)-4-((3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl)piperazine, Actin Assembly Inhibitor XVI, Ras Activation Inhibitor, Tubulin Polymerization Inhibitor IX
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Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 729605-21-4 | C₂₁H₂₁ClN₄O |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 480150-5MG | 5 mg |
| Description | |
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| Overview | A cell-permeable pyrazole compound that is shown to prevent in vitro tubulin polymerization (IC50 = 0.2 µM) by targeting Colchicine (Cat. No. 234115) binding site (Kd = 0.3 µM) in cell-free assays and induce blebs formation in HUVEC cultures by perturbing both tubulin microtubles and actin cytoskeleton structures. Unrelated to its effects on actin and tubulin filaments, XRP44X is also reported to block the activations of Ras and its downstream effector molecules, such as Raf, MEK, Erk, Rsk, and Net (Elk-3/SAP-2/Erp), upon FGF-2 (Cat. No. 341595) stimulation. Potently inhibits the growth of HUVEC, NIH3T3, as well as 9 other cancer cell lines in antiproliferation assays (IC50 ≤11.3 nM). |
| Catalogue Number | 480150 |
| Brand Family | Calbiochem® |
| Synonyms | 1-(3-Chlorophenyl)-4-((3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl)piperazine, Actin Assembly Inhibitor XVI, Ras Activation Inhibitor, Tubulin Polymerization Inhibitor IX |
| References | |
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| References | Wasylyk, C., et al. 2008. Cancer Res. 68, 1275. |
| Product Information | |
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| CAS number | 729605-21-4 |
| Form | White solid |
| Hill Formula | C₂₁H₂₁ClN₄O |
| Chemical formula | C₂₁H₂₁ClN₄O |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥98% by HPLC |
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| Safety Information | |
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| S Phrase | S: 22-24/25-36/37/39 Do not breathe dust. Avoid contact with skin and eyes. Wear suitable protective clothing, gloves and eye/face protection. |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Identification Number | |
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| Catalog Number | GTIN |
| 480150-5MG | 4055977201260 |
Documentation
Ras-Net (Elk-3) Pathway Inhibitor, XRP44X - CAS 729605-21-4 - Calbiochem SDS
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Ras-Net (Elk-3) Pathway Inhibitor, XRP44X - CAS 729605-21-4 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 480150 |
References
| Reference overview |
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| Wasylyk, C., et al. 2008. Cancer Res. 68, 1275. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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