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557451 RXRα Inhibitor, K-80003 - Calbiochem

557451
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₃H₂₃FO₂

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557451-10MG
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      Glass bottle 10 mg
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      Description
      OverviewA cell permeable, Sulindac analog with IC50=2.4 µM for RXRα binding, and unlike other NSAIDs, is inactive toward COX2 and COX1 even at 1 mM. The compound displays potent inhibition of RXRα dependent AKT Activation in both PC3 and A549 cells, and is RXRα but not RXRγ expression dependent as shown in PC3 cells. It is further shown to inhibit the interaction of RXRα/Δ80 with p85α either in the absence or presence of TNF-α. Induces PARP cleavage and caspase-8 activation at 50 µM when used with TNF-α. Furthermore, it almost completely suppresses colony formation of HeLa/RXRα/1-134 and RXRα/Δ80 cells at 25 µM in vitro, and exhibits potent inhibition of tumor growth in vivo when dosed at 60mg/kg.
      Catalogue Number557451
      Brand Family Calbiochem®
      SynonymsK-80003
      References
      ReferencesZhou, H., et al. 2010. Cancer Cell 17, 560.
      Product Information
      FormYellow solid
      Hill FormulaC₂₃H₂₃FO₂
      Chemical formulaC₂₃H₂₃FO₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      RXRα Inhibitor, K-80003 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      RXRα Inhibitor, K-80003 - Calbiochem Certificates of Analysis

      TitleLot Number
      557451

      References

      Reference overview
      Zhou, H., et al. 2010. Cancer Cell 17, 560.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-February-2011 RFH
      SynonymsK-80003
      DescriptionA cell permeable, Sulindac analog with IC50=2.4 µM for RXRα binding, and unlike other NSAIDs, is inactive toward COX2 and COX1 even at 1 mM. The compound displays potent inhibition of RXRα dependent AKT Activation in both PC3 and A549 cells, and is RXRα but not RXRγ expression dependent as shown in PC3 cells. It is further shown to inhibit the interaction of RXRα/Δ80 with p85α either in the absence or presence of TNF-α. Induces PARP cleavage and caspase-8 activation at 50 µM when used with TNF-α. Furthermore, it almost completely suppresses colony formation of HeLa/RXRα/1-134 and RXRα/Δ80 cells at 25 µM in vitro, and exhibits potent inhibition of tumor growth in vivo when dosed at 60 mg/kg.
      FormYellow solid
      Chemical formulaC₂₃H₂₃FO₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C.
      Toxicity Standard Handling
      ReferencesZhou, H., et al. 2010. Cancer Cell 17, 560.