538439 RV1088 - CAS 1229606-73-8 - Calbiochem

538439
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₃₃H₃₄N₆O₄ 1229606-73-8

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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable, naphthalene based compound that acts as a narrow spectrum kinase inhibitor and reduces pro-inflammatory cytokine synthesis in LPS-activated primary human macrophages (IC50 = 0.63 and 1.66 nM for TNFα and IL-6), monocytes (IC50 = 0.97, 1.1, and 1.32 nM for TNFα, IL-6, and IL-8), and synovial fibroblasts (5.45 and 1.61 nM for IL-6 and IL-8). Shown to simultaneously inhibit the activity of p38α, p38γ, and Src (c-Src and Hck, and Syk). Also reported to inhibit antigen-induced release of beta-Hex, LTC4, and PGD2 (IC50 = 18, 11, and 21 nM, respectively) in cord blood derived mast cells.

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number538439
      Brand Family Calbiochem®
      SynonymsN-[4-[[4-[[[[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]amino]carbonyl]amino]-1-naphthalenyl]oxy]-2-pyridinyl]-2-methoxyacetamide
      DescriptionRV1088
      References
      ReferencesTo, W. S., et al. 2015. Br. J. Pharmacol. 172, 3805.
      Product Information
      CAS number1229606-73-8
      FormPinkish-brown solid
      Hill FormulaC₃₃H₃₄N₆O₄
      Chemical formulaC₃₃H₃₄N₆O₄
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetp-38α, p38γ, c-Src, Hck and SyK
      Primary Target IC<sub>50</sub>5.45 nM, 1.61 nM for IL-6, IL-8 inhibition respectively in activated rheumatoid arthritis synovial fibroblasts
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      RV1088 - CAS 1229606-73-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      To, W. S., et al. 2015. Br. J. Pharmacol. 172, 3805.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-August-2016 JSW
      SynonymsN-[4-[[4-[[[[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]amino]carbonyl]amino]-1-naphthalenyl]oxy]-2-pyridinyl]-2-methoxyacetamide
      DescriptionA cell-permeable, naphthalene based compound that acts as a narrow spectrum kinase inhibitor and reduces pro-inflammatory cytokine synthesis in LPS-activated primary human macrophages (IC50 = 0.63 and 1.66 nM for TNFα and IL-6), monocytes (IC50 = 0.97, 1.1, and 1.32 nM for TNFα, IL-6, and IL-8), and synovial fibroblasts (5.45 and 1.61 nM for IL-6 and IL-8). Shown to simultaneously inhibit the activity of p38α, p38γ, and Src (c-Src and Hck, and Syk). Also reported to inhibit antigen-induced release of beta-Hex, LTC4, and PGD2 (IC50 = 18, 11, and 21 nM, respectively) in cord blood derived mast cells.
      FormPinkish-brown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1229606-73-8
      Chemical formulaC₃₃H₃₄N₆O₄
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesTo, W. S., et al. 2015. Br. J. Pharmacol. 172, 3805.