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508147 RS 127445 Hydrochloride - CAS 199864-86-3 - Calbiochem

508147
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
199864-86-3C₁₇H₁₆FN₃·HCl

Products

Catalog NumberPackaging Qty/Pack
5.08147.0001 Glass bottle 10 mg
Description
OverviewA selective, high affinity , orally bioavailable 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi = 9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites including the closely related 5-HT2A and 5-HT2C receptors. In isolated human cells, RS-127445 exbhited an IC50 greater than 10 µM.
Catalogue Number508147
Brand Family Calbiochem®
References
ReferencesSharif, N. A. et al. 2006. J. Ocul. Pharmacol. Ther. 22, 389.
Bonhaus, D. W. et al. 1999. Br. J. Pharmacol. 127, 1075.
Bonhaus, D. W. et al. 1999. Br. J. Pharmacol. 127, 1075.
Product Information
CAS number199864-86-3
FormOff-white solid
Hill FormulaC₁₇H₁₆FN₃·HCl
Chemical formulaC₁₇H₁₆FN₃·HCl
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Target5-HT2B
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.08147.0001 04055977242850

Documentation

References

Reference overview
Sharif, N. A. et al. 2006. J. Ocul. Pharmacol. Ther. 22, 389.
Bonhaus, D. W. et al. 1999. Br. J. Pharmacol. 127, 1075.
Bonhaus, D. W. et al. 1999. Br. J. Pharmacol. 127, 1075.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-October-2013 JSW
DescriptionA selective, high affinity , orally bioavailable 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi = 9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites including the closely related 5-HT2A and 5-HT2C receptors. In isolated human cells, RS-127445 exbhited an IC50 greater than 10 µM.
FormOff-white solid
CAS number199864-86-3
Chemical formulaC₁₇H₁₆FN₃·HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mM) or Ethanol (100 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSharif, N. A. et al. 2006. J. Ocul. Pharmacol. Ther. 22, 389.
Bonhaus, D. W. et al. 1999. Br. J. Pharmacol. 127, 1075.
Bonhaus, D. W. et al. 1999. Br. J. Pharmacol. 127, 1075.