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530389 RIPK3 Inhibitor, GSKʹ872 - CAS 1346546-69-7 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
1346546-69-7C₁₉H₁₇N₃O₂S₂

Products

Catalog NumberPackaging Qty/Pack
5.30389.0001 Glass bottle 10 mg
Description
OverviewA cell-permeable quinolinyl-benzothiazolamine compound that is reported to act as a RIP3-selective kinase inhibitor with >1,000-fold selectivity over a vast majority of more than 300 other kinases, including RIP1. RIP1 inhibitor Nec-1 (30 µM; Cat. Nos. 480065 & 505224) can be employed in conjunction with GSK'872 (3 µM) in delineating RIP1- vs. RIP3-dependency in Toll-like receptors- (TLRs) mediated necrosis and TNFR1-initiated necroptosis in the presence or absence of caspase inhibitor Z-VAD-FMK (25 µM; Cat. Nos. 627609 & 627610).
Catalogue Number530389
Brand Family Calbiochem®
SynonymsNecrosis Inhibitor V, RIPK3 Inhibitor I, N-(6-(Isopropylsulfonyl)quinolin-4-yl)benzo[d]thiazol-5-amine, RIP3 Kinase Inhibitor I, Receptor-Interacting Protein Kinase 3 Inhibitor I, GSK-872
References
ReferencesKaiser, W.J., et al. 2013. J. Biol. Chem. 288, 31268.
Product Information
CAS number1346546-69-7
FormYellow solid
Hill FormulaC₁₉H₁₇N₃O₂S₂
Chemical formulaC₁₉H₁₇N₃O₂S₂
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetRIP3 Kinase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze 9-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.30389.0001 04055977260762

Documentation

RIPK3 Inhibitor, GSKʹ872 - CAS 1346546-69-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

RIPK3 Inhibitor, GSKʹ872 - CAS 1346546-69-7 - Calbiochem Certificates of Analysis

TitleLot Number
530389

References

Reference overview
Kaiser, W.J., et al. 2013. J. Biol. Chem. 288, 31268.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-September-2014 JSW
SynonymsNecrosis Inhibitor V, RIPK3 Inhibitor I, N-(6-(Isopropylsulfonyl)quinolin-4-yl)benzo[d]thiazol-5-amine, RIP3 Kinase Inhibitor I, Receptor-Interacting Protein Kinase 3 Inhibitor I, GSK-872
DescriptionA cell-permeable quinolinyl-benzothiazolamine compound that is reported to act as a RIP3-selective kinase inhibitor with >1,000-fold selectivity over a vast majority of more than 300 other kinases, including RIP1. RIP1 inhibitor Nec-1 (30 µM; Cat. Nos. 480065 & 505224) and genetic knockdown can be employed in conjunction with GSK'872 (3 µM) in delineating RIP1- vs. RIP3-dependency in Toll-like receptors- (TLRs) mediated necrosis and TNFR1-initiated necroptosis in the presence or absence of caspase inhibitor Z-VAD-FMK (25 µM; Cat. Nos. 627609 & 627610). While RIP3 and its downstream substrate MLKL are shown to mediate TLR3-initiated necrosis in the presence of Z-VAD-FMK in murine macrophage (BMDM & J774), fibroblast (3T3-SA & MEF), and endothelial (SVEC4-10) cultures, only in BMDM & J774 macrophage cultures is RIP1 involvement also seen in TLR3-mediated necrosis.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1346546-69-7
Chemical formulaC₁₉H₁₇N₃O₂S₂
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze 9-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKaiser, W.J., et al. 2013. J. Biol. Chem. 288, 31268.