554718 REV-ERBα Antagonist, SR8278 - Calbiochem

554718
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₈H₁₉NO₃S₂

Pricing & Availability

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554718-5MG
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      Glass bottle 5 mg
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      Description
      OverviewA cell-permeable REV-ERB antagonist that inhibits REV-ERBα transcriptional repression activity (EC50 = 0.47 µM) in a REV-ERB target gene assay. It is also shown to block the ability of GSK4112 to enhance REV-ERB-&alpha-dependent repression (EC50 = 0.35 µM) in a co-transfection assay. Treatment of HepG2 cells with SR8278 at 10 µM results in a significant increase in the expression of either G6Pase and PEPCK mRNA expression, consistent with its antagonistic role against endogenous heme.
      Catalogue Number554718
      Brand Family Calbiochem®
      SynonymsSR8278 SR 8278
      References
      ReferencesKojetin, D., et al. 2010, Chem Bio in press
      Product Information
      FormWhite to yellow-brown solid or gum
      Hill FormulaC₁₈H₁₉NO₃S₂
      Chemical formulaC₁₈H₁₉NO₃S₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity>95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      REV-ERBα Antagonist, SR8278 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      REV-ERBα Antagonist, SR8278 - Calbiochem Certificates of Analysis

      TitleLot Number
      554718

      References

      Reference overview
      Kojetin, D., et al. 2010, Chem Bio in press
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-February-2020 JSW
      SynonymsSR8278 SR 8278
      DescriptionA cell-permeable REV-ERB antagonist that inhibits REV-ERBα transcriptional repression activity (EC50 = 0.47 µM) in a REV-ERB target gene assay. It is also shown to block the ability of GSK4112 to enhance REV-ERB-&alpha-dependent repression (EC50 = 0.35 µM) in a co-transfection assay. Treatment of HepG2 cells with SR8278 at 10 µM results in a significant increase in the expression of either G6Pase and PEPCK mRNA expression, consistent with its antagonistic role against endogenous heme.
      FormWhite to yellow-brown solid or gum
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₈H₁₉NO₃S₂
      Structure formulaStructure formula
      Purity>95% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
      Toxicity Regulatory Review
      ReferencesKojetin, D., et al. 2010, Chem Bio in press