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504535 QNZ46 - CAS 1237744-13-6 - Calbiochem

504535
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Key Specifications Table

Empirical FormulaCAS #
C₂₄H₁₇N₃O₆ 1237744-13-6

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      Glass bottle 5 mg
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      Description
      OverviewA noncompetitive and voltage-independent antagonist selective for NR2C/D containing NMDA receptors (IC50 = 6, 3, 229, and >300 µM for NR2C, NR2D, NR2A, and NR2B, respectively). Inhibition on NR2C/D containing NMDA receptors is glutamate-binding, but not glycine-binding, dependent. Represents a new class of noncompetitive subunit-selective NMDA receptor antagonists. With more than 100-fold selectivity for recombinant NMDA receptors over AMPA and kainate receptors.
      Catalogue Number504535
      Brand Family Calbiochem®
      Synonyms4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-Benzoic acid, NMDA Antagonist VIII
      References
      ReferencesMayer, M., et al. 2013. Annu. Rev. Physiol. 75, 1.
      Hansen, K., 2011. J. Neurosci. 9, 3650.
      Mosley, C., et al. 2010. J. Med. Chem. 53, 5476.
      Product Information
      CAS number1237744-13-6
      FormYellow powder
      Hill FormulaC₂₄H₁₇N₃O₆
      Chemical formulaC₂₄H₁₇N₃O₆
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNMDA receptors
      Primary Target IC<sub>50</sub>6, 3, 229, and >300 →M for NR2C, NR2D, NR2A, and NR2B, respectively.
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      QNZ46 - CAS 1237744-13-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Mayer, M., et al. 2013. Annu. Rev. Physiol. 75, 1.
      Hansen, K., 2011. J. Neurosci. 9, 3650.
      Mosley, C., et al. 2010. J. Med. Chem. 53, 5476.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-June-2013 JSW
      Synonyms4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-Benzoic acid, NMDA Antagonist VIII
      DescriptionA noncompetitive and voltage-independent antagonist selective for NR2C/D containing NMDA receptors (IC50 = 6, 3, 229, and >300 µM for NR2C, NR2D, NR2A, and NR2B, respectively). Inhibition on NR2C/D containing NMDA receptors is glutamate-binding, but not glycine-binding, dependent. Represents a new class of noncompetitive subunit-selective NMDA receptor antagonists. With more than 100-fold selectivity for recombinant NMDA receptors over AMPA and kainate receptors.
      FormYellow powder
      CAS number1237744-13-6
      Chemical formulaC₂₄H₁₇N₃O₆
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml). Slight warming is required for complete solubilization.
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesMayer, M., et al. 2013. Annu. Rev. Physiol. 75, 1.
      Hansen, K., 2011. J. Neurosci. 9, 3650.
      Mosley, C., et al. 2010. J. Med. Chem. 53, 5476.