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504535 QNZ46 - CAS 1237744-13-6 - Calbiochem

QNZ46 - CAS 1237744-13-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NMDA Antagonist VIII, 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-Benzoic acid

Primary Target: NMDA receptors
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
1237744-13-6C₂₄H₁₇N₃O₆

Products

Catalog NumberPackaging Qty/Pack
5.04535.0001 Glass bottle 5 mg
Description
OverviewA noncompetitive and voltage-independent antagonist selective for NR2C/D containing NMDA receptors (IC50 = 6, 3, 229, and >300 µM for NR2C, NR2D, NR2A, and NR2B, respectively). Inhibition on NR2C/D containing NMDA receptors is glutamate-binding, but not glycine-binding, dependent. Represents a new class of noncompetitive subunit-selective NMDA receptor antagonists. With more than 100-fold selectivity for recombinant NMDA receptors over AMPA and kainate receptors.
Catalogue Number504535
Brand Family Calbiochem®
SynonymsNMDA Antagonist VIII, 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-Benzoic acid
References
ReferencesMayer, M., et al. 2013. Annu. Rev. Physiol. 75, 1.
Hansen, K., 2011. J. Neurosci. 9, 3650.
Mosley, C., et al. 2010. J. Med. Chem. 53, 5476.
Product Information
CAS number1237744-13-6
FormYellow powder
Hill FormulaC₂₄H₁₇N₃O₆
Chemical formulaC₂₄H₁₇N₃O₆
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNMDA receptors
Primary Target IC<sub>50</sub>6, 3, 229, and >300 →M for NR2C, NR2D, NR2A, and NR2B, respectively.
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

QNZ46 - CAS 1237744-13-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Mayer, M., et al. 2013. Annu. Rev. Physiol. 75, 1.
Hansen, K., 2011. J. Neurosci. 9, 3650.
Mosley, C., et al. 2010. J. Med. Chem. 53, 5476.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-June-2013 JSW
SynonymsNMDA Antagonist VIII, 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-Benzoic acid
DescriptionA noncompetitive and voltage-independent antagonist selective for NR2C/D containing NMDA receptors (IC50 = 6, 3, 229, and >300 µM for NR2C, NR2D, NR2A, and NR2B, respectively). Inhibition on NR2C/D containing NMDA receptors is glutamate-binding, but not glycine-binding, dependent. Represents a new class of noncompetitive subunit-selective NMDA receptor antagonists. With more than 100-fold selectivity for recombinant NMDA receptors over AMPA and kainate receptors.
FormYellow powder
CAS number1237744-13-6
Chemical formulaC₂₄H₁₇N₃O₆
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (5 mg/ml). Slight warming is required for complete solubilization.
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesMayer, M., et al. 2013. Annu. Rev. Physiol. 75, 1.
Hansen, K., 2011. J. Neurosci. 9, 3650.
Mosley, C., et al. 2010. J. Med. Chem. 53, 5476.