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539209 Protein Arginine N-Methyltransferase Inhibitor, AMI-1 - Calbiochem

539209
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₁H₁₂N₂Na₄O₉S₂

Pricing & Availability

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539209-5MG
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      Description
      OverviewA cell-permeable, symmetrical sulfonated urea compound that acts as a potent, specific and non-AdoMet (S-adenosyl-L-methionine, SAM)-competitive inhibitor of protein arginine N-methyltransferases (PRMTs; IC50 = 8.81 µM for PRMT1 and 3.03 for yeast-RMT1p) with minimal effect on lysine methyltransferases. Inhibits nuclear receptor reporter gene activation in MCF-7 cells, and HIV-1 RT polymerase (IC50 = 5 µM).
      Catalogue Number539209
      Brand Family Calbiochem®
      SynonymsPRMT Inhibitor I
      References
      ReferencesCheng, D., et al. 2004. J. Biol. Chem. 279, 23892.
      Skillman, A.G., et al. 2002. Bioorg. Chem. 30, 443.
      Product Information
      ATP CompetitiveN
      FormSolid
      Hill FormulaC₂₁H₁₂N₂Na₄O₉S₂
      Chemical formulaC₂₁H₁₂N₂Na₄O₉S₂
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetProtein arginine N-methyltransferases (PRMTs)
      Primary Target IC<sub>50</sub>8.81 µM for PRMT1 and 3.03 for yeast-RMT1p
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Protein Arginine N-Methyltransferase Inhibitor, AMI-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Protein Arginine N-Methyltransferase Inhibitor, AMI-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      539209

      References

      Reference overview
      Cheng, D., et al. 2004. J. Biol. Chem. 279, 23892.
      Skillman, A.G., et al. 2002. Bioorg. Chem. 30, 443.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-March-2008 JSW
      SynonymsPRMT Inhibitor I
      DescriptionA cell-permeable, potent, specific, and non-AdoMet (S-adenosyl-L-methionine, SAM)-competitive inhibitor of protein arginine N-methyltransferases (PRMTs; IC50 = 8.81 µM for PRMT1 and 3.03 µM for yeast-RMT1p) with minimal effect on lysine methyltransferases. Inhibits nuclear receptor reporter gene activation in MCF-7 cells, and HIV-1 RT polymerase (IC50 = 5 µM).
      FormSolid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₁H₁₂N₂Na₄O₉S₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (50 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesCheng, D., et al. 2004. J. Biol. Chem. 279, 23892.
      Skillman, A.G., et al. 2002. Bioorg. Chem. 30, 443.