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539163 Proteasome Inhibitor III - Calbiochem

Proteasome Inhibitor III, CAS 179324-22-2, is a reversible proteasome inhibitor that is structurally similar to MG-132, but displays much higher potency (Ki = 30 pM vs. 4 nM for MG-132).

Proteasome Inhibitor III - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: MG-262, Z-LLL-B(OH)₂

Primary Target: proteasome
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
179324-22-2C₂₅H₄₂BN₃O₆

Products

Catalog NumberPackaging Qty/Pack
539163-100UG Glass bottle 100 μg
Description
OverviewA boronic acid-based, reversible proteasome inhibitor that is structurally similar to MG-132 (Cat. No. 474790) but displays much higher potency (Ki = 30 pM vs. 4 nM for MG-132).
Catalogue Number539163
Brand Family Calbiochem®
SynonymsMG-262, Z-LLL-B(OH)₂
References
ReferencesAdams, J., et al. 1998. Bioorg. Med. Chem. Lett. 8, 333.
Mc Cormack, T., et al. 1997. J. Biol. Chem. 272, 26103.
Product Information
CAS number179324-22-2
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₅H₄₂BN₃O₆
Chemical formulaC₂₅H₄₂BN₃O₆
ReversibleY
Quality LevelMQ100
Applications
ApplicationProteasome Inhibitor III, CAS 179324-22-2, is a reversible proteasome inhibitor that is structurally similar to MG-132, but displays much higher potency (Ki = 30 pM vs. 4 nM for MG-132).
Biological Information
Primary Targetproteasome
Primary Target K<sub>i</sub>30 pM against proteasome
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceZ-Leu-Leu-Leu-B(OH)₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Proteasome Inhibitor III - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Proteasome Inhibitor III - Calbiochem Certificates of Analysis

TitleLot Number
539163

References

Reference overview
Adams, J., et al. 1998. Bioorg. Med. Chem. Lett. 8, 333.
Mc Cormack, T., et al. 1997. J. Biol. Chem. 272, 26103.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-September-2008 RFH
SynonymsMG-262, Z-LLL-B(OH)₂
DescriptionA boronic acid-based, reversible proteasome inhibitor that is structurally similar to MG-132 (Cat. No. 474790) but displays much higher potency (Ki = 0.03 nM versus 4 nM for MG-132).
FormWhite solid
CAS number179324-22-2
Chemical formulaC₂₅H₄₂BN₃O₆
Peptide SequenceZ-Leu-Leu-Leu-B(OH)₂
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from moisture
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Toxicity Standard Handling
ReferencesAdams, J., et al. 1998. Bioorg. Med. Chem. Lett. 8, 333.
Mc Cormack, T., et al. 1997. J. Biol. Chem. 272, 26103.