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537012 Prolyl Endopeptidase Inhibitor III, KYP-2047 - Calbiochem

The Prolyl Endopeptidase Inhibitor III, KYP-2047 controls the biological activity of Prolyl Endopeptidase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (S)-1-((S)-1-(4-phenylbutanoyl)-pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile, 4-phenylbutanoyl-Lprolyl-2(S)-cyanopyrrolidine, PREP inhibitor III, KYP-2047

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537012
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₀H₂₅N₃O₂

Products

Catalog NumberPackaging Qty/Pack
537012-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable, potent, fast-acting, and selective inhibitor of prolyl oligopeptidase (PREP) (Ki = 23 pM). Reported to cross the blood-brain barrier. Inhibits about 85% PREP activity within 10 minutes of administration and exhibits a half-life of about 4.8 hours. Exhibits higher lipophilicity that increases its penetration across biological membranes in vivo. Maximum plasma and brain levels are achieved within 10 minutes following its i.p. administration. Shown to block oxidative-stress induced α-synuclein aggregation and clearance in cellular and animal models of Parkinson's disease. Also shown to improve cognitive performance in young rats (1-5 mg/kg) in a dose-dependent manner.
Catalogue Number537012
Brand Family Calbiochem®
Synonyms(S)-1-((S)-1-(4-phenylbutanoyl)-pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile, 4-phenylbutanoyl-Lprolyl-2(S)-cyanopyrrolidine, PREP inhibitor III, KYP-2047
References
ReferencesJarho, E., et al. 2004. J. Med. Chem. 47, 5605.
Venalainen, J., et al. 2011. Biochem. Pharmacol. 71, 683.
Jalkanen, A., et al. 2006. Basic & Clin. Pharmac. & Tox. 100, 132.
Jalkanen, A., et al. 2011. Basic & Clin. Pharmac. & Tox. 109, 443.
Klimaviciusa, L., et al. 2012. Journ. Neuros. Methods. 204, 104.
Myohanen, T., et al. 2012. Brit. J. Pharm. 166, 1097.
Product Information
FormClear, colorless oil
Hill FormulaC₂₀H₂₅N₃O₂
Chemical formulaC₂₀H₂₅N₃O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Prolyl Endopeptidase Inhibitor III, KYP-2047 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Prolyl Endopeptidase Inhibitor III, KYP-2047 - Calbiochem Certificates of Analysis

TitleLot Number
537012

References

Reference overview
Jarho, E., et al. 2004. J. Med. Chem. 47, 5605.
Venalainen, J., et al. 2011. Biochem. Pharmacol. 71, 683.
Jalkanen, A., et al. 2006. Basic & Clin. Pharmac. & Tox. 100, 132.
Jalkanen, A., et al. 2011. Basic & Clin. Pharmac. & Tox. 109, 443.
Klimaviciusa, L., et al. 2012. Journ. Neuros. Methods. 204, 104.
Myohanen, T., et al. 2012. Brit. J. Pharm. 166, 1097.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-November-2012 JSW
Synonyms(S)-1-((S)-1-(4-phenylbutanoyl)-pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile, 4-phenylbutanoyl-Lprolyl-2(S)-cyanopyrrolidine, PREP inhibitor III, KYP-2047
DescriptionA cell-permeable, potent, fast-acting, and selective inhibitor of prolyl oligopeptidase (PREP) (Ki = 23 pM). Reported to cross the blood-brain barrier. Inhibits about 85% PREP activity within 10 minutes of administration and exhibits a half-life of about 4.8 hours. Exhibits higher lipophilicity that increases its penetration across biological membranes in vivo. Maximum plasma and brain levels are achieved within 10 minutes following its i.p. administration. Shown to block oxidative-stress induced α-synuclein aggregation and clearance in cellular and animal models of Parkinson's disease. Also shown to improve cognitive performance in young rats (1-5 mg/kg) in a dose-dependent manner.
FormClear, colorless oil
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₀H₂₅N₃O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesJarho, E., et al. 2004. J. Med. Chem. 47, 5605.
Venalainen, J., et al. 2011. Biochem. Pharmacol. 71, 683.
Jalkanen, A., et al. 2006. Basic & Clin. Pharmac. & Tox. 100, 132.
Jalkanen, A., et al. 2011. Basic & Clin. Pharmac. & Tox. 109, 443.
Klimaviciusa, L., et al. 2012. Journ. Neuros. Methods. 204, 104.
Myohanen, T., et al. 2012. Brit. J. Pharm. 166, 1097.