537009 Progranulin, CF, Mouse, Recombinant

537009
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Overview

Replacement Information

Key Specifications Table

Purity
≥90% by SDS-PAGE

Pricing & Availability

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537009-50UG
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      Glass bottle 50 μg
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      Description
      OverviewRecombinant, mouse progranulin, consisting of amino acids 18-589, fused at the C-terminus to a His•Tag® sequence, and expressed in NS0-derived mouse myeloma cells. Progranulin is an ubiquitously expressed, secreted glycoprotein that is involved in regulation of cell proliferation.
      Catalogue Number537009
      Brand Family Calbiochem®
      SynonymsPC cell-derived growth factor (PCDGF)
      References
      ReferencesLiu, Y. et al. 2007. BMC Cancer 7, 22.
      Xu, K. et al. 2007. J. Biol. Chem. 282, 11347.
      Barreda, D.R. et al. 2004. Dev. Comp. Immunol. 28, 727.
      Davidson, B. et al. 2004. Cancer 100, 2139.
      Sun, X. et al. 2004. Am. J. Respir. Cell Mol. Biol. 30, 510.
      Gonzalez, E.M. et al. 2003. J. Biol. Chem. 278, 38113.
      He, Z. et al. 2003. Nat. Med. 9, 225.
      He, Z. and Bateman, A. 2003. J. Mol. Med. 81, 600.
      Jones, M.B. et al. 2003. Gynecol. Oncol. 88, S136.
      Wang, W. et al. 2003. Clin. Cancer Res. 9, 2221.
      Suzuki, M. and Nishiahara, M. 2002. Mol. Genet. Metab. 75, 31.
      Zhu, J. et al. 2002. Cell 111, 867.
      Lu, R. and Serrero, G. 2000. Proc. Natl. Acad. Sci. U.S.A. 97, 3993.
      Justen, H.P. et al. 2000. Mol. Cell Biol. Res. Commun. 3, 165.
      Zanocco Marani, T. et al. 1999. Cancer Res. 59, 5331.
      Zhang, H. and G. Serrero 1998. Proc. Natl. Acad. Sci. U.S.A. 95, 14202.
      Zhou, J. et al. 1993. J. Biol. Chem. 268, 10863.
      Plowman, G.D. et al. 1992. J. Biol. Chem. 267, 13073.
      Bateman, A. et al. 1990. Biochem. Biophys. Res. Commun. 173, 1161.
      Product Information
      FormLyophilized
      FormulationLyophilized from 0.2 µm filtered PBS.
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activitySignificantly enhances neurite outgrowth of E18 rat embryonic cortical neurons using 4-16 µg/ml progranulin immobilized on nitrocelluose-coated microplates.
      Purity≥90% by SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: ≤1.0 EU/µg protein
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Progranulin, CF, Mouse, Recombinant SDS

      Title

      Safety Data Sheet (SDS) 

      Progranulin, CF, Mouse, Recombinant Certificates of Analysis

      TitleLot Number
      537009

      References

      Reference overview
      Liu, Y. et al. 2007. BMC Cancer 7, 22.
      Xu, K. et al. 2007. J. Biol. Chem. 282, 11347.
      Barreda, D.R. et al. 2004. Dev. Comp. Immunol. 28, 727.
      Davidson, B. et al. 2004. Cancer 100, 2139.
      Sun, X. et al. 2004. Am. J. Respir. Cell Mol. Biol. 30, 510.
      Gonzalez, E.M. et al. 2003. J. Biol. Chem. 278, 38113.
      He, Z. et al. 2003. Nat. Med. 9, 225.
      He, Z. and Bateman, A. 2003. J. Mol. Med. 81, 600.
      Jones, M.B. et al. 2003. Gynecol. Oncol. 88, S136.
      Wang, W. et al. 2003. Clin. Cancer Res. 9, 2221.
      Suzuki, M. and Nishiahara, M. 2002. Mol. Genet. Metab. 75, 31.
      Zhu, J. et al. 2002. Cell 111, 867.
      Lu, R. and Serrero, G. 2000. Proc. Natl. Acad. Sci. U.S.A. 97, 3993.
      Justen, H.P. et al. 2000. Mol. Cell Biol. Res. Commun. 3, 165.
      Zanocco Marani, T. et al. 1999. Cancer Res. 59, 5331.
      Zhang, H. and G. Serrero 1998. Proc. Natl. Acad. Sci. U.S.A. 95, 14202.
      Zhou, J. et al. 1993. J. Biol. Chem. 268, 10863.
      Plowman, G.D. et al. 1992. J. Biol. Chem. 267, 13073.
      Bateman, A. et al. 1990. Biochem. Biophys. Res. Commun. 173, 1161.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-June-2011 RFH
      SynonymsPC cell-derived growth factor (PCDGF)
      DescriptionRecombinant, mouse progranulin, consisting of amino acids 18-589, fused at the C-terminus to a His•Tag® sequence, and expressed in NS0-derived mouse myeloma cells. Progranulin is an ubiquitously expressed, secreted glycoprotein that is involved in regulation of cell proliferation.
      FormLyophilized
      FormulationLyophilized from 0.2 µm filtered PBS.
      Purity≥90% by SDS-PAGE
      ContaminantsEndotoxin: ≤1.0 EU/µg protein
      Biological activitySignificantly enhances neurite outgrowth of E18 rat embryonic cortical neurons using 4-16 µg/ml progranulin immobilized on nitrocelluose-coated microplates.
      SolubilityReconstitute to 250 µg/ml with sterile PBS.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLiu, Y. et al. 2007. BMC Cancer 7, 22.
      Xu, K. et al. 2007. J. Biol. Chem. 282, 11347.
      Barreda, D.R. et al. 2004. Dev. Comp. Immunol. 28, 727.
      Davidson, B. et al. 2004. Cancer 100, 2139.
      Sun, X. et al. 2004. Am. J. Respir. Cell Mol. Biol. 30, 510.
      Gonzalez, E.M. et al. 2003. J. Biol. Chem. 278, 38113.
      He, Z. et al. 2003. Nat. Med. 9, 225.
      He, Z. and Bateman, A. 2003. J. Mol. Med. 81, 600.
      Jones, M.B. et al. 2003. Gynecol. Oncol. 88, S136.
      Wang, W. et al. 2003. Clin. Cancer Res. 9, 2221.
      Suzuki, M. and Nishiahara, M. 2002. Mol. Genet. Metab. 75, 31.
      Zhu, J. et al. 2002. Cell 111, 867.
      Lu, R. and Serrero, G. 2000. Proc. Natl. Acad. Sci. U.S.A. 97, 3993.
      Justen, H.P. et al. 2000. Mol. Cell Biol. Res. Commun. 3, 165.
      Zanocco Marani, T. et al. 1999. Cancer Res. 59, 5331.
      Zhang, H. and G. Serrero 1998. Proc. Natl. Acad. Sci. U.S.A. 95, 14202.
      Zhou, J. et al. 1993. J. Biol. Chem. 268, 10863.
      Plowman, G.D. et al. 1992. J. Biol. Chem. 267, 13073.
      Bateman, A. et al. 1990. Biochem. Biophys. Res. Commun. 173, 1161.