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5291 Polymyxin B Sulfate - CAS 1405-20-5 - Calbiochem

5291
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Overview

Replacement Information

Key Specifications Table

CAS #
1405-20-5

Pricing & Availability

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5291-1GM
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      5291-500MG
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          5291-5GM
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              Description
              OverviewAn antibiotic that inhibits phospholipid-sensitive Ca2+-dependent protein kinases. Mixture of polymyxin B1 sulfate and polymyxin B2 sulfate. Binds to cell wall and makes it more permeable, causing fluid uptake. Effective against Gram-negative bacteria.
              Catalogue Number5291
              Brand Family Calbiochem®
              SynonymsAerosporin
              References
              ReferencesLucas, M., et al. 1994. Biochem. Pharmacol. 47, 667.
              Ngezahayo, A. and Kolb, H.A. 1993. Pflugers Arch. 422, 413.
              Kubo, M. and Okada, Y. 1992. J. Physiol. 456, 351.
              Strasser, S.H., et al. 1992. Circ. Res. 70, 1304.
              Hegemann, L., et al. 1991. Eur. J. Pharmacol. 207, 17.
              Inaba, H. and Filkins, J.P. 1991. Am. J. Physiol. 261, R26.
              Marra, M.N., et al. 1990. J. Immunol. 144, 662.
              Product Information
              CAS number1405-20-5
              FormWhite to off-white solid
              Quality LevelMQ200
              Applications
              Biological Information
              Biological activityPotency: ≥7500 IU/mg
              Primary TargetPhospholipid sensitive Ca2+ dependent protein kinases
              Physicochemical Information
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSTR1150000
              Safety Information
              R PhraseR: 22

              Harmful if swallowed.
              S PhraseS: 36

              Wear suitable protective clothing.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Harmful
              Storage +15°C to +30°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 year at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              Polymyxin B Sulfate - CAS 1405-20-5 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              Polymyxin B Sulfate - CAS 1405-20-5 - Calbiochem Certificates of Analysis

              TitleLot Number
              5291

              References

              Reference overview
              Lucas, M., et al. 1994. Biochem. Pharmacol. 47, 667.
              Ngezahayo, A. and Kolb, H.A. 1993. Pflugers Arch. 422, 413.
              Kubo, M. and Okada, Y. 1992. J. Physiol. 456, 351.
              Strasser, S.H., et al. 1992. Circ. Res. 70, 1304.
              Hegemann, L., et al. 1991. Eur. J. Pharmacol. 207, 17.
              Inaba, H. and Filkins, J.P. 1991. Am. J. Physiol. 261, R26.
              Marra, M.N., et al. 1990. J. Immunol. 144, 662.

              Brochure

              Title
              Antibiotics Profiler
              PKC Pathway Poster PDF ( 676 KB )
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision07-January-2011 JSW
              SynonymsAerosporin
              DescriptionAn antibiotic that inhibits phospholipid sensitive Ca2+-dependent protein kinase. Mixture of polymyxin B1 sulfate and polymyxin B2 sulfate.
              FormWhite to off-white solid
              CAS number1405-20-5
              RTECSTR1150000
              Biological activityPotency: ≥7500 IU/mg
              SolubilityH₂O (25 mg/ml)
              Storage +15°C to +30°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 year at -20°C.
              Toxicity Harmful
              Merck USA index14, 7573
              ReferencesLucas, M., et al. 1994. Biochem. Pharmacol. 47, 667.
              Ngezahayo, A. and Kolb, H.A. 1993. Pflugers Arch. 422, 413.
              Kubo, M. and Okada, Y. 1992. J. Physiol. 456, 351.
              Strasser, S.H., et al. 1992. Circ. Res. 70, 1304.
              Hegemann, L., et al. 1991. Eur. J. Pharmacol. 207, 17.
              Inaba, H. and Filkins, J.P. 1991. Am. J. Physiol. 261, R26.
              Marra, M.N., et al. 1990. J. Immunol. 144, 662.

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              Categories

              Life Science Research > Inhibitors and Biochemicals > Biochemicals > Antibiotics > Antimicrobial Agents
              Life Science Research > Cell Culture and Systems > Antibiotics & Selection Agents