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516620 Peroxynitrite - Calbiochem

516620
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516620-1SET
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      Alu drum 1 set
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      Description
      OverviewSynthesized from isoamyl nitrite and hydrogen peroxide. Peroxynitrite (ONOO) is a cell-permeable strong biological oxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine. Has been implicated in a variety of pathophysiological conditions including acute respiratory distress syndrome (ARDS), arthritis, atherosclerosis, inflammatory bowel disease, ischemia-reperfusion, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity, and septic shock.
      Note: 1 set = 2 x 1 ml.
      Catalogue Number516620
      Brand Family Calbiochem®
      References
      ReferencesMarla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243.
      Sakuma, S., et al. 1997. Biochem. Biophys. Res. Commun. 230, 476.
      Lymar, S.V., et al. 1996. Biochemistry 35, 7855.
      Uppu, R.M., and Pryor, W.A. 1996. Methods Enzymol. 269, 322.
      Ischiropoulos, H., and al-Medhi, A.B. 1995. FEBS Lett. 364, 279.
      Product Information
      ATP CompetitiveN
      FormYellow liquid
      FormulationSupplied in 4.7% NaOH at 160-200 mM.
      ReversibleN
      Quality LevelMQ100
      Applications
      ApplicationPeroxynitrite, CAS 14042-01-4, is a cell-permeable, short-lived, strong biological oxidant agent that reacts with and can damage DNA, membrane phospholipids, sulfhydryl groups, and tyrosine.
      Biological Information
      Primary TargetOxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 8-20/22-34

      Contact with combustible material may cause fire.
      Harmful by inhalation and if swallowed.
      Causes burns.
      S PhraseS: 3-28-36/37/39-45

      Keep in a cool place.

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Oxidizer
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage ≤ -70°C
      Protect from Light Protect from light
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsProtect from heat, light, metal ions, and air. Peroxynitrite is unstable; thaw rapidly, dispense into aliquots, purge tubes with an inert gas, and freeze -70°C. Activity decreases ~2% /day at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Peroxynitrite - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Peroxynitrite - Calbiochem Certificates of Analysis

      TitleLot Number
      516620

      References

      Reference overview
      Marla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243.
      Sakuma, S., et al. 1997. Biochem. Biophys. Res. Commun. 230, 476.
      Lymar, S.V., et al. 1996. Biochemistry 35, 7855.
      Uppu, R.M., and Pryor, W.A. 1996. Methods Enzymol. 269, 322.
      Ischiropoulos, H., and al-Medhi, A.B. 1995. FEBS Lett. 364, 279.

      Brochure

      Title
      Pathways and Biomarkers of Oxidative Stress (EMD)
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-November-2007 JSW
      DescriptionSynthesized from isoamyl nitrite and hydrogen peroxide. Peroxynitrite (ONOO–) is a strong biological oxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine. It has been implicated in a variety of patho-physiological conditions including acute respiratory distress syndrome (ARDS), arthritis, atherosclerosis, inflammatory bowel disease, ischemia-reperfusion, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity, and septic shock. This product decomposes or isomerizes at pH 8 or less; the half-life at pH 7.5 is ~1.5 s. ε302 nm = 1670M-1cm-1 in 0.1 MNaOH.
      FormYellow liquid
      FormulationSupplied in 4.7% NaOH at 160-200 mM.
      Intert gas (Yes/No) Packaged under inert gas
      SolubilityPeroxynitrite is soluble in aqueous buffers that have been pre-purged with an inert gas and pre-cooled to 4°C.
      Storage ≤ -70°C
      Protect from light
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsProtect from heat, light, metal ions, and air. Peroxynitrite is unstable; thaw rapidly, dispense into aliquots, purge tubes with an inert gas, and freeze -70°C. Activity decreases ~2% /day at -20°C.
      Toxicity Oxidizer
      ReferencesMarla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243.
      Sakuma, S., et al. 1997. Biochem. Biophys. Res. Commun. 230, 476.
      Lymar, S.V., et al. 1996. Biochemistry 35, 7855.
      Uppu, R.M., and Pryor, W.A. 1996. Methods Enzymol. 269, 322.
      Ischiropoulos, H., and al-Medhi, A.B. 1995. FEBS Lett. 364, 279.