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540215 PTP CD45 Inhibitor - CAS 345630-40-2 - Calbiochem

540215
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₉H₁₇NO₃ 345630-40-2

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540215-5MG
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      Plastic ampoule 5 mg
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      Description
      OverviewA cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45 (IC50 = 200 nM or 3.8 µM using pNPP or phosphorylated Ick505 peptide as a substrate, respectively). Does not effectively inhibit PTPIB (IC50 >30 µM using phosphorylated Ick505 peptide as a substrate). The phenanthrenedione group does not function as a thiol oxidizing agent. One of the most potent inhibitor of phosphatase tensin homolog deleted on chromosome 10 (PTEN) that enhances PIP3 signaling in a variety of cells and improves the efficacy of granulocyte transfusion in murine models of neutropenia-related pneumonia.
      Catalogue Number540215
      Brand Family Calbiochem®
      SynonymsN-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethyl-propionamide, PTPase CD45 Inhibitor, Protein Tyrosine Phosphatase CD45 Inhibitor, SF1670, PTP Inhibitor XIX, PTP1B Inhibitor VI, PTPN2/TCPTP Inhibitor, SHP1 Inhibitor VII, YPTP1 Inhibitor, YOP Inhibitor, PTEN Inhibitor V
      References
      ReferencesLi, Y., et al. 2011. Blood 117, 6702.
      Urbanek, R.A., et al. 2001. J. Med. Chem. 44, 1777.
      Product Information
      CAS number345630-40-2
      ATP CompetitiveN
      FormRed-violet solid
      Hill FormulaC₁₉H₁₇NO₃
      Chemical formulaC₁₉H₁₇NO₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCD45 using pNPP as a substrate
      Primary Target IC<sub>50</sub>200 nM or 3.8 µM against CD45 using pNPP or phosphorylated Ick505 peptide as a substrate, respectively
      Purity≥ 97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      PTP CD45 Inhibitor - CAS 345630-40-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PTP CD45 Inhibitor - CAS 345630-40-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      540215

      References

      Reference overview
      Li, Y., et al. 2011. Blood 117, 6702.
      Urbanek, R.A., et al. 2001. J. Med. Chem. 44, 1777.

      Citations

      Title
      Kirchberger, S., et al. 2008. Blood 112, 1240. Baba, M., et al. 2007. Journal of Leukocyte Biology 81, 1002.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-July-2012 JSW
      SynonymsN-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethyl-propionamide, PTPase CD45 Inhibitor, Protein Tyrosine Phosphatase CD45 Inhibitor, SF1670, PTP Inhibitor XIX, PTP1B Inhibitor VI, PTPN2/TCPTP Inhibitor, SHP1 Inhibitor VII, YPTP1 Inhibitor, YOP Inhibitor, PTEN Inhibitor V
      DescriptionA cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45 (IC50 = 200 nM using pNPP as the substrate, 3.8 µM for CD45 lck, >30 µM for PTP1B lck) that displays anti-proliferative properties. Also reported to potently block T-cell receptor-mediated proliferation (IC50 = 100 nM). Shown to be less cytotoxic (CC50 = 3.5 µM) than other 1,2-naphthalenedione analogs. The phenanthrenedione group does not function as a thiol oxidizing agent. One of the most potent inhibitor of phosphatase tensin homolog deleted on chromosome 10 (PTEN) that enhances PIP3 signaling in a variety of cells and improves the efficacy of granulocyte transfusion in murine models of neutropenia-related pneumonia.
      FormRed-violet solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number345630-40-2
      Chemical formulaC₁₉H₁₇NO₃
      Structure formulaStructure formula
      Purity≥ 97% by HPLC
      SolubilityDMSO (5 mg/ml) or Ethanol (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Harmful
      ReferencesLi, Y., et al. 2011. Blood 117, 6702.
      Urbanek, R.A., et al. 2001. J. Med. Chem. 44, 1777.
      CitationKirchberger, S., et al. 2008. Blood 112, 1240. Baba, M., et al. 2007. Journal of Leukocyte Biology 81, 1002.