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540215 PTP CD45 Inhibitor - CAS 345630-40-2 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
345630-40-2C₁₉H₁₇NO₃

Products

Catalog NumberPackaging Qty/Pack
540215-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45 (IC50 = 200 nM or 3.8 µM using pNPP or phosphorylated Ick505 peptide as a substrate, respectively). Does not effectively inhibit PTPIB (IC50 >30 µM using phosphorylated Ick505 peptide as a substrate). The phenanthrenedione group does not function as a thiol oxidizing agent. One of the most potent inhibitor of phosphatase tensin homolog deleted on chromosome 10 (PTEN) that enhances PIP3 signaling in a variety of cells and improves the efficacy of granulocyte transfusion in murine models of neutropenia-related pneumonia.
Catalogue Number540215
Brand Family Calbiochem®
SynonymsN-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethyl-propionamide, PTPase CD45 Inhibitor, Protein Tyrosine Phosphatase CD45 Inhibitor, PTP Inhibitor XIX, PTP1B Inhibitor VI, PTPN2/TCPTP Inhibitor, SHP1 Inhibitor VII, YPTP1 Inhibitor, YOP Inhibitor, PTEN Inhibitor V, SF1670
References
ReferencesLi, Y., et al. 2011. Blood 117, 6702.
Urbanek, R.A., et al. 2001. J. Med. Chem. 44, 1777.
Product Information
CAS number345630-40-2
ATP CompetitiveN
FormRed-violet solid
Hill FormulaC₁₉H₁₇NO₃
Chemical formulaC₁₉H₁₇NO₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCD45 using pNPP as a substrate
Primary Target IC<sub>50</sub>200 nM or 3.8 µM against CD45 using pNPP or phosphorylated Ick505 peptide as a substrate, respectively
Purity≥ 97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
540215-5MG 07790788051372

Documentation

PTP CD45 Inhibitor - CAS 345630-40-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PTP CD45 Inhibitor - CAS 345630-40-2 - Calbiochem Certificates of Analysis

TitleLot Number
540215

References

Reference overview
Li, Y., et al. 2011. Blood 117, 6702.
Urbanek, R.A., et al. 2001. J. Med. Chem. 44, 1777.

Citations

Title
Kirchberger, S., et al. 2008. Blood 112, 1240. Baba, M., et al. 2007. Journal of Leukocyte Biology 81, 1002.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-July-2012 JSW
SynonymsN-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethyl-propionamide, PTPase CD45 Inhibitor, Protein Tyrosine Phosphatase CD45 Inhibitor, PTP Inhibitor XIX, PTP1B Inhibitor VI, PTPN2/TCPTP Inhibitor, SHP1 Inhibitor VII, YPTP1 Inhibitor, YOP Inhibitor, PTEN Inhibitor V, SF1670
DescriptionA cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45 (IC50 = 200 nM using pNPP as the substrate, 3.8 µM for CD45 lck, >30 µM for PTP1B lck) that displays anti-proliferative properties. Also reported to potently block T-cell receptor-mediated proliferation (IC50 = 100 nM). Shown to be less cytotoxic (CC50 = 3.5 µM) than other 1,2-naphthalenedione analogs. The phenanthrenedione group does not function as a thiol oxidizing agent. One of the most potent inhibitor of phosphatase tensin homolog deleted on chromosome 10 (PTEN) that enhances PIP3 signaling in a variety of cells and improves the efficacy of granulocyte transfusion in murine models of neutropenia-related pneumonia.
FormRed-violet solid
Intert gas (Yes/No) Packaged under inert gas
CAS number345630-40-2
Chemical formulaC₁₉H₁₇NO₃
Structure formulaStructure formula
Purity≥ 97% by HPLC
SolubilityDMSO (5 mg/ml) or Ethanol (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Harmful
ReferencesLi, Y., et al. 2011. Blood 117, 6702.
Urbanek, R.A., et al. 2001. J. Med. Chem. 44, 1777.
CitationKirchberger, S., et al. 2008. Blood 112, 1240. Baba, M., et al. 2007. Journal of Leukocyte Biology 81, 1002.