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528245 PLD Inhibitor, FIPI - Calbiochem

528245
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₃H₂₄FN₅O₂

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528245-5MG
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      Glass bottle 5 mg
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      Description
      OverviewA cell-permeable, PLD1/2 inhibitor (IC50 = 1 nM and 10 nM for PLD1 and PLD2, respectively, in a CHO cell based assay, and IC50 = 20 nM for PLD2 in a biochemical assay), that displays no activity toward MitoPLD, and is selective for PLD1 and PLD2 over other PLD superfamily enzymes. It is also shown to block PLD2-dependent effects on cytoskeletal reorganization and cell trafficking in CHO cells, and diminish fMLP-directed neutrophil chemotaxis in HL60 cells at 750 nM. Unlike 1-butanol, this compound does not affect glucose-stimulated insulin secretion in Min6 pancreatic β-cells.
      Catalogue Number528245
      Brand Family Calbiochem®
      SynonymsCompound 4k, PLD Inhibitor I
      References
      ReferencesSu, W., et al. 2009. Mol Pharmacol 75, 437.
      Monovich, L., et al. 2007. Bioorg Med Chem 17, 2310.
      Product Information
      FormOff-white powder
      Hill FormulaC₂₃H₂₄FN₅O₂
      Chemical formulaC₂₃H₂₄FN₅O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      PLD Inhibitor, FIPI - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PLD Inhibitor, FIPI - Calbiochem Certificates of Analysis

      TitleLot Number
      528245

      References

      Reference overview
      Su, W., et al. 2009. Mol Pharmacol 75, 437.
      Monovich, L., et al. 2007. Bioorg Med Chem 17, 2310.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-August-2012 JSW
      SynonymsCompound 4k, PLD Inhibitor I
      DescriptionA cell-permeable, PLD1/2 inhibitor (IC50 = 1 nM and 10 nM for PLD1 and PLD2, respectively, in a CHO cell based assay, and IC50 = 20 nM for PLD2 in a biochemical assay), that displays no activity toward MitoPLD, and is selective for PLD1 and PLD2 over other PLD superfamily enzymes. It is also shown to block PLD2-dependent effects on cytoskeletal reorganization and cell trafficking in CHO cells, and diminish fMLP-directed neutrophil chemotaxis in HL60 cells at 750 nM. Unlike 1-butanol, this compound does not affect glucose-stimulated insulin secretion in Min6 pancreatic β-cells.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₃H₂₄FN₅O₂
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSu, W., et al. 2009. Mol Pharmacol 75, 437.
      Monovich, L., et al. 2007. Bioorg Med Chem 17, 2310.