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527450 PKR Inhibitor - CAS 608512-97-6 - Calbiochem

527450
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₃H₈N₄OS 608512-97-6

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527450-5MG
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      Glass bottle 5 mg
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      Description
      OverviewAn imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC50 = 210 nM) and rescue PKR-dependent translation block (IC50 = 100 nM). Inactive control is also available (Cat. No. 527455). Shown to increase the late phase of long-lasting synaptic potentiation, and enhance long-term memory in mice. Also available as a 50 mM solution in DMSO (Cat. No. 527451).
      Catalogue Number527450
      Brand Family Calbiochem®
      SynonymsPKRi, Double-stranded RNA-dependent Protein Kinase Inhibitor, C16, Double-stranded RNA-activated Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I
      References
      ReferencesZhu, P.J., et al. 2011. Cell 147, 1384.
      Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.
      Product Information
      CAS number608512-97-6
      ATP CompetitiveN
      FormOrange to orange brown solid
      Hill FormulaC₁₃H₈N₄OS
      Chemical formulaC₁₃H₈N₄OS
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationPKR Inhibitor, CAS 608512-97-6, is a potent, ATP-binding site directed PKR inhibitor that blocks RNA-induced PKR autophosphorylation (IC50 = 210 nM). Rescue PKR-dependent translation block.
      Biological Information
      Primary TargetPKR
      Primary Target IC<sub>50</sub>210 nM inhibiting RNA-induced PKR autophosphorylation and 100 nM in rescuing PKR-dependent translation block
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      PKR Inhibitor - CAS 608512-97-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PKR Inhibitor - CAS 608512-97-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      527450

      References

      Reference overview
      Zhu, P.J., et al. 2011. Cell 147, 1384.
      Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-April-2018 JSW
      SynonymsPKRi, Double-stranded RNA-dependent Protein Kinase Inhibitor, C16, Double-stranded RNA-activated Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I
      DescriptionAn imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC50 = 210 nM) and rescue PKR-dependent translation block (IC50 = 100 nM). Shown to increase the late phase of long-lasting synaptic potentiation, and enhance long-term memory in mice. Inactive control is also available (Cat. No. 527455).
      FormOrange to orange brown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number608512-97-6
      Chemical formulaC₁₃H₈N₄OS
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesZhu, P.J., et al. 2011. Cell 147, 1384.
      Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.