Product Information
Applications
ApplicationPKM2 Activator II, DASA, is a cell-permeable, potent, and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM).
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

PKM2 Activator II, DASA - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PKM2 Activator II, DASA - Calbiochem Certificates of Analysis

TitleLot Number
550602

References

Reference overview
Anastasiou, D., et al. 2011. Science 334, 1278.
Boxer, M.B., et al. 2010. J. Med. Chem. 53, 1048.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-October-2012 JSW
Synonyms1-(2,6-Difluorophenylsulfonyl)-4-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)piperazine, Pyruvate Kinase M2 Activator II
DescriptionA cell-permeable diarylsulfonamide (DASA) compound that acts as a potent and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM). Pretreatment of A549 (adenocarcinomic human alveolar basal epithelial cells) with DASA-10 (~10 µM) prevents hydrogen peroxide, diamide, and hypoxia-induced inactivation of PKM2. DASA treatment is shown to cause a diminution in cellular glutathione levels, and higher oxidative stress-induced cell death.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₈H₁₈F₂N₂O₆S₂
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesAnastasiou, D., et al. 2011. Science 334, 1278.
Boxer, M.B., et al. 2010. J. Med. Chem. 53, 1048.

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Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Activators > Kinases Activators