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526523 PIM1/2 Kinase Inhibitor V - CAS 327033-36-3 - Calbiochem

The PIM1/2 Kinase Inhibitor V, also referenced under CAS 327033-36-3, controls the biological activity of PIM1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (Z)-5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione, SMI-4a

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526523
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
327033-36-3C₁₁H₆F₃NO₂S

Products

Catalog NumberPackaging Qty/Pack
526523-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor against Pim-1/2 kinases (IC50 = 24 nM and 100 nM against Pim-1 and Pim-2, respectively), while exhibiting little or no activity against a panel of 58 other kinases (≤20% inhibition at 5 µM). One hour inhibitor treatment (0.5 µM) of HEK-293T cultures at the end of a 4 hour 32PO4 incubation period results in nearly complete inhibition of the autophosphorylation of overexpressed Pim-1. Comparing to Inhibitor VI (Cat. No. 526524), Inhibitor V is less reactive towards DYRK1α (20% vs. 68% inhibition with respective inhibitor at 5 µM) and more potent in PC3 human prostate cancer cell killing (IC50 = 17 vs. 48 µM with respective inhibitor).
Catalogue Number526523
Brand Family Calbiochem®
Synonyms(Z)-5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione, SMI-4a
References
ReferencesLin,Y., et al. 2009. Blood In press.
Xia, Z., et al. 2009. J. Med. Chem. 52, 74.
Product Information
CAS number327033-36-3
FormLight beige solid
Hill FormulaC₁₁H₆F₃NO₂S
Chemical formulaC₁₁H₆F₃NO₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

PIM1/2 Kinase Inhibitor V - CAS 327033-36-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PIM1/2 Kinase Inhibitor V - CAS 327033-36-3 - Calbiochem Certificates of Analysis

TitleLot Number
526523

References

Reference overview
Lin,Y., et al. 2009. Blood In press.
Xia, Z., et al. 2009. J. Med. Chem. 52, 74.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-April-2011 RFH
Synonyms(Z)-5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione, SMI-4a
DescriptionA cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor against Pim-1/2 kinases (IC50 = 24 nM and 100 nM against Pim-1 and Pim-2, respectively), while exhibiting little or no activity against a panel of 58 other kinases (≤20% inhibition at 5 µM). One h inhibitor treatment (0.5 µM) of HEK-293T cultures at the end of a 4 h 32PO4 incubation period results in nearly complete inhibition of the autophosphorylation of overexpressed Pim-1. Comparing to Inhibitor VI (Cat. No. 526524), Inhibitor V is less reactive towards DYRK1α (20% vs. 68% inhibition with respective inhibitor at 5 µM) and more potent in PC3 human prostate cancer cell killing (IC50 = 17 vs. 48 µM with respective inhibitor).
FormLight beige solid
Intert gas (Yes/No) Packaged under inert gas
CAS number327033-36-3
Chemical formulaC₁₁H₆F₃NO₂S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesLin,Y., et al. 2009. Blood In press.
Xia, Z., et al. 2009. J. Med. Chem. 52, 74.