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528114 PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem

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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
6318-41-8C₁₁H₇NO₄S
Description
OverviewA cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive, and isoform-selctive PI 3-K inhibitor (IC50 = 0.07, 0.24, 1.45, and 1.70 µM for the γ, α, β, and δ isoform, respectively) with little or no activity against a panel of 38 other commonly studied kinases (<20% inhibition at 1.0 µM). Exhibits similar pharmacokinetics as LY 294002 (Cat. Nos. 440202 & 440204) via oral administration, but is 3-times as potent (ED50 = 27.35 mg/kg, p.o.) in blocking rhRNATES-induced neutrophil peritoneal recruitment in mice in vivo. Also reported to exhibit significant in vivo prophylactic efficacy against carrageenan-induced tissue swelling in a rat paw edema model (100 mg/kg, p.o.).
Catalogue Number528114
Brand Family Calbiochem®
Synonyms5-(Benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, AS041164, PI 3-K Inhibitor VII
References
ReferencesFerrandi, C., et al. 2007. J. Pharmacol. Exp. Ther. 322, 923.
Product Information
CAS number6318-41-8
FormYellow solid
Hill FormulaC₁₁H₇NO₄S
Chemical formulaC₁₁H₇NO₄S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 43

May cause sensitization by skin contact.
S PhraseS: 36/37-45

Wear suitable protective clothing and gloves.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
528114 0

Documentation

PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem Certificates of Analysis

TitleLot Number
528114

References

Reference overview
Ferrandi, C., et al. 2007. J. Pharmacol. Exp. Ther. 322, 923.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-April-2011 RFH
Synonyms5-(Benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, AS041164, PI 3-K Inhibitor VII
DescriptionA cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive, and isoform-selctive PI 3-K inhibitor (IC50 = 0.07, 0.24, 1.45, and 1.70 µM for the γ, α, β, and δ isoform, respectively) with little or no activity against a panel of 38 other commonly studied kinases (<20% inhibition at 1.0 µM). Exhibits similar pharmacokinetics as LY 294002 (Cat. Nos. 440202 & 440204) via oral administration, but is 3-times as potent (ED50 = 27.35 mg/kg, p.o.) in blocking rhRNATES-induced neutrophil peritoneal recruitment in mice in vivo. Also reported to exhibit significant in vivo prophylactic efficacy against carrageenan-induced tissue swelling in a rat paw edema model (100 mg/kg, p.o.).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number6318-41-8
Chemical formulaC₁₁H₇NO₄S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (40 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesFerrandi, C., et al. 2007. J. Pharmacol. Exp. Ther. 322, 923.