528108 PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem

528108
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₁H₅F₂NO₄S 648449-76-7

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528108-5MG
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      Description
      OverviewA cell-permeable thiazolidinedione compound that acts as a potent and ATP-competitive inhibitor of PI 3-Kγ (Ki = 180 nM; IC50 = 250 nM). Exhibits great selectivity over PI 3-Kα (IC50 = 4.5 µM), PI 3-Kβ and δ (IC50 > 20 µM), and shows little effect towards a large panel of receptors, unrelated enzymes, ion channels, and 38 commonly studied kinases. Shown to block MCP-1-mediated monocyte chemotaxis in vitro and exhibit better in vivo efficacy than LY294002 (Cat. No. 440202 and 440204) in blocking RANTES- or thioglycollate-induced peritoneal neutrophil recruitment by oral administration in a murine peritonitis model.
      Catalogue Number528108
      Brand Family Calbiochem®
      Synonyms5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, PI 3-K Inhibitor II
      References
      ReferencesBilancio, A., et al. 2006. Blood 107, 642.
      Camps, M., et al. 2005. Nat. Med. 11, 936.
      Product Information
      CAS number648449-76-7
      ATP CompetitiveY
      FormOff-white solid
      Hill FormulaC₁₁H₅F₂NO₄S
      Chemical formulaC₁₁H₅F₂NO₄S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPI 3-Kγ
      Primary Target IC<sub>50</sub>250 nM against PI 3-Kγ
      Primary Target K<sub>i</sub>180 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      528108

      References

      Reference overview
      Bilancio, A., et al. 2006. Blood 107, 642.
      Camps, M., et al. 2005. Nat. Med. 11, 936.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-March-2008 RFH
      Synonyms5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, PI 3-K Inhibitor II
      DescriptionA cell-permeable thiazolidinedione compound that acts as a potent and ATP-competitive inhibitor of PI 3-Kγ (Ki = 180 nM; IC50 = 250 nM). Exhibits great selectivity over PI 3-Kα (IC50 = 4.5 µM), PI 3-Kβ and δ (IC50 > 20 µM), and shows little effect towards a large panel of receptors, unrelated enzymes, ion channels, and 38 commonly studied kinases. Shown to block MCP-1-mediated monocyte chemotaxis in vitro and exhibit better in vivo efficacy than LY294002 (Cat. No. 440202 and 440204) in blocking RANTES- or thioglycollate-induced peritoneal neutrophil recruitment by oral administration in a murine peritonitis model.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number648449-76-7
      Chemical formulaC₁₁H₅F₂NO₄S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesBilancio, A., et al. 2006. Blood 107, 642.
      Camps, M., et al. 2005. Nat. Med. 11, 936.