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528108 PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem

The PI 3-Kγ Inhibitor II, also referenced under CAS 648449-76-7, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, PI 3-K Inhibitor II

Primary Target: PI 3-Kγ
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
648449-76-7C₁₁H₅F₂NO₄S

Products

Catalog NumberPackaging Qty/Pack
528108-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable thiazolidinedione compound that acts as a potent and ATP-competitive inhibitor of PI 3-Kγ (Ki = 180 nM; IC50 = 250 nM). Exhibits great selectivity over PI 3-Kα (IC50 = 4.5 µM), PI 3-Kβ and δ (IC50 > 20 µM), and shows little effect towards a large panel of receptors, unrelated enzymes, ion channels, and 38 commonly studied kinases. Shown to block MCP-1-mediated monocyte chemotaxis in vitro and exhibit better in vivo efficacy than LY294002 (Cat. No. 440202 and 440204) in blocking RANTES- or thioglycollate-induced peritoneal neutrophil recruitment by oral administration in a murine peritonitis model.
Catalogue Number528108
Brand Family Calbiochem®
Synonyms5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, PI 3-K Inhibitor II
References
ReferencesBilancio, A., et al. 2006. Blood 107, 642.
Camps, M., et al. 2005. Nat. Med. 11, 936.
Product Information
CAS number648449-76-7
ATP CompetitiveY
FormOff-white solid
Hill FormulaC₁₁H₅F₂NO₄S
Chemical formulaC₁₁H₅F₂NO₄S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPI 3-Kγ
Primary Target IC<sub>50</sub>250 nM against PI 3-Kγ
Primary Target K<sub>i</sub>180 nM
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
528108-5MG 04055977270501

Documentation

PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem Certificates of Analysis

TitleLot Number
528108

References

Reference overview
Bilancio, A., et al. 2006. Blood 107, 642.
Camps, M., et al. 2005. Nat. Med. 11, 936.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-March-2008 RFH
Synonyms5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, PI 3-K Inhibitor II
DescriptionA cell-permeable thiazolidinedione compound that acts as a potent and ATP-competitive inhibitor of PI 3-Kγ (Ki = 180 nM; IC50 = 250 nM). Exhibits great selectivity over PI 3-Kα (IC50 = 4.5 µM), PI 3-Kβ and δ (IC50 > 20 µM), and shows little effect towards a large panel of receptors, unrelated enzymes, ion channels, and 38 commonly studied kinases. Shown to block MCP-1-mediated monocyte chemotaxis in vitro and exhibit better in vivo efficacy than LY294002 (Cat. No. 440202 and 440204) in blocking RANTES- or thioglycollate-induced peritoneal neutrophil recruitment by oral administration in a murine peritonitis model.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number648449-76-7
Chemical formulaC₁₁H₅F₂NO₄S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesBilancio, A., et al. 2006. Blood 107, 642.
Camps, M., et al. 2005. Nat. Med. 11, 936.