528112 PI 3-Kγ/CKII Inhibitor - CAS 1138220-19-5 - Calbiochem

528112
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₄H₈FNO₄S 1138220-19-5

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528112-5MG
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      Description
      OverviewA cell-permeable furanyl-thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor of PI 3-Kγ and CKII (IC50 = 20 nM). It inhibits other PI 3-K isotypes (IC50 = 0.94, 20, and 20 µM for α, β, δ, respectively) and MKK7β (IC50 >10 µM) only at much higher concentrations and exhibits little activity against 77 other commonly studied kinases even at concentrations as high as 10 µM. Shown to inhibit stimulated Akt phosphorylation in cells in vitro and offer blockage of thioglycollate-induced neutrophil recruitment in a murine peritonitis model in vivo.
      Catalogue Number528112
      Brand Family Calbiochem®
      Synonyms(5-(4-Fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione, AS-252424, PI 3-K Inhibitor XII
      References
      ReferencesPomel, V., et al. 2006. J. Med. Chem. 49, 3857.
      Product Information
      CAS number1138220-19-5
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₁₄H₈FNO₄S
      Chemical formulaC₁₄H₈FNO₄S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPI 3-Kγ/CKII
      Primary Target IC<sub>50</sub>20 nM against PI 3-Kγ and CKII
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      PI 3-Kγ/CKII Inhibitor - CAS 1138220-19-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      528112

      References

      Reference overview
      Pomel, V., et al. 2006. J. Med. Chem. 49, 3857.

      Brochure

      Title
      Biologics 33.2
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-April-2011 RFH
      Synonyms(5-(4-Fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione, AS-252424, PI 3-K Inhibitor XII
      DescriptionA cell-permeable furanyl-thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor of PI 3-Kγ and CKII (IC50 = 20 nM). It inhibits other PI 3-K isotypes (IC50 = 0.94, 20, and 20 µM for α, β, δ, respectively) and MKK7β (IC50 >10 µM) only at much higher concentrations and exhibits little activity against 77 other commonly studied kinases even at concentrations as high as 10 µM. Shown to inhibit stimulated Akt phosphorylation in cells in vitro and offer blockage of thioglycollate-induced neutrophil recruitment in a murine peritonitis model in vivo.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1138220-19-5
      Chemical formulaC₁₄H₈FNO₄S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (20 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesPomel, V., et al. 2006. J. Med. Chem. 49, 3857.