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504632 PHCCC - CAS 1161205-27-1 - Calbiochem

PHCCC - CAS 1161205-27-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (E)-1,1a,7,7a-Tetrahydro-7-(hydroxyimino)-N-phenylcyclopropa[b]chromene-1a-carboxamide

Primary Target: mGlu₄ receptors
504632
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
1161205-27-1C₁₇H₁₄N₂O₃

Products

Catalog NumberPackaging Qty/Pack
5.04632.0001 Glass bottle 10 mg
Description
OverviewA potent positive allosteric modulator selective for mGlu4 receptors (EC50 = 3 µM). Also, a less potent agonist of mGlu6 receptors (EC50 = 15 µM). Biologically active admitted systematically. Often used in assessing the functional roles of mGlu4 receptors or group III mGlu receptors in a variety of research areas, such as epileptic seizures, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease.
Catalogue Number504632
Brand Family Calbiochem®
Synonyms(E)-1,1a,7,7a-Tetrahydro-7-(hydroxyimino)-N-phenylcyclopropa[b]chromene-1a-carboxamide
References
ReferencesOh, H., et al. 2013. Psychopharmacol. 1, 9.
Dickerson, W., 2012. Neurodegen. Diseases Manag. 2, 221.
Le Poul, E., et al. 2012. J. Pharmacol. & Exp. Therap. 343, 167.
Szczurowska, E., 2012. Physiol. Res. 61, 619.
Beqollari, D., et al. 2008. Eur. J. Pharmacol. 589, 4.
Niswender, M., et al. 2008. Mol. Pharmacol. 74, 1345.
Stachowicz, K., et al. 2004. Eur. J. Pharmacol. 498, 153.
Maj, M., et al. 2003. Neuropharmacol. 45, 895.
Marino, J., et al. 2003. PNAS. 100, 13668.
Product Information
CAS number1161205-27-1
FormWhite solid
Hill FormulaC₁₇H₁₄N₂O₃
Chemical formulaC₁₇H₁₄N₂O₃
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetmGlu₄ receptors
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

PHCCC - CAS 1161205-27-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Oh, H., et al. 2013. Psychopharmacol. 1, 9.
Dickerson, W., 2012. Neurodegen. Diseases Manag. 2, 221.
Le Poul, E., et al. 2012. J. Pharmacol. & Exp. Therap. 343, 167.
Szczurowska, E., 2012. Physiol. Res. 61, 619.
Beqollari, D., et al. 2008. Eur. J. Pharmacol. 589, 4.
Niswender, M., et al. 2008. Mol. Pharmacol. 74, 1345.
Stachowicz, K., et al. 2004. Eur. J. Pharmacol. 498, 153.
Maj, M., et al. 2003. Neuropharmacol. 45, 895.
Marino, J., et al. 2003. PNAS. 100, 13668.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-July-2013 JSW
Synonyms(E)-1,1a,7,7a-Tetrahydro-7-(hydroxyimino)-N-phenylcyclopropa[b]chromene-1a-carboxamide
DescriptionA potent positive allosteric modulator selective for mGlu4 receptors (EC50 = 3 µM). Also, a less potent agonist of mGlu6 receptors (EC50 = 15 µM). Biologically active admitted systematically. Often used in assessing the functional roles of mGlu4 receptors or group III mGlu receptors in a variety of research areas, such as epileptic seizures, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease.
FormWhite solid
CAS number1161205-27-1
Chemical formulaC₁₇H₁₄N₂O₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesOh, H., et al. 2013. Psychopharmacol. 1, 9.
Dickerson, W., 2012. Neurodegen. Diseases Manag. 2, 221.
Le Poul, E., et al. 2012. J. Pharmacol. & Exp. Therap. 343, 167.
Szczurowska, E., 2012. Physiol. Res. 61, 619.
Beqollari, D., et al. 2008. Eur. J. Pharmacol. 589, 4.
Niswender, M., et al. 2008. Mol. Pharmacol. 74, 1345.
Stachowicz, K., et al. 2004. Eur. J. Pharmacol. 498, 153.
Maj, M., et al. 2003. Neuropharmacol. 45, 895.
Marino, J., et al. 2003. PNAS. 100, 13668.