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509664 PDX1 Inducer, BRD7552 - Calbiochem

A cell permeable, reversible inducer of PDX1 expression. Its action is dependent on the presence of FOXA2 in cells.

PDX1 Inducer, BRD7552 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Pancreatic and Duodenal Homeobox 1 Inducer

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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₃₃H₃₃N₃O₁₅

Products

Catalog NumberPackaging Qty/Pack
5.09664.0001 Glass bottle 5 mg
Description
OverviewA cell permeable, glucose-derived diversity oriented synthesized compound that acts as reversible inducer of PDX1 expression in human PANC-1 cells, primary human islets, and human duct derived cells in a dose-and time-dependent manner with maximal effect observed on day 9 at 5 µM. Its action is dependent on the presence of FOXA2 in cells as FOXA2 knockdown cells treated with this compound do not exhibit any effect on PDX1 expression. Shown to increase H3 acetylation and H3K4me3 and reduce H3K9me3, which is consistent with its transcriptional activation of PDX1. Prolonged treatment of PANC-1 cells (9 days) increases the expression of insulin mRNA and proteins levels. Does not affect cell number and does not influence apoptotic cell death in PANC-1 cells.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number509664
Brand Family Calbiochem®
SynonymsPancreatic and Duodenal Homeobox 1 Inducer
References
ReferencesYuan, Y., et al. 2013. Chem. Bio. 20, 1513.
Product Information
FormWhite powder
Hill FormulaC₃₃H₃₃N₃O₁₅
Chemical formulaC₃₃H₃₃N₃O₁₅
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Unstable in DMSO.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Catalog Number GTIN
5.09664.00014055977241006

Documentation

PDX1 Inducer, BRD7552 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Yuan, Y., et al. 2013. Chem. Bio. 20, 1513.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-March-2014 JSW
SynonymsPancreatic and Duodenal Homeobox 1 Inducer
DescriptionA cell permeable, glucose-derived diversity oriented synthesized compound that acts as reversible inducer of PDX1 expression in human PANC-1 cells, primary human islets, and human duct derived cells in a dose-and time-dependent manner with maximal effect observed on day 9 at 5 µM. Its action is dependent on the presence of FOXA2 in cells as FOXA2 knockdown cells treated with this compound do not exhibit any effect on PDX1 expression. Shown to increase H3 acetylation and H3K4me3 and reduce H3K9me3, which is consistent with its transcriptional activation of PDX1. Prolonged treatment of PANC-1 cells (9 days) increases the expression of insulin mRNA and proteins levels. Does not affect cell number and does not influence apoptotic cell death in PANC-1 cells.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₃H₃₃N₃O₁₅
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityEthanol (25 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Unstable in DMSO.
Toxicity Standard Handling
ReferencesYuan, Y., et al. 2013. Chem. Bio. 20, 1513.