524748 PDE4D Inhibitor, GEBR-7b - Calbiochem

524748
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₁H₃₀N₂O₅

Pricing & Availability

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524748-5MG
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      Glass bottle 5 mg
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      Description
      OverviewA cell permeable, potent, and selective oxime PDE4D inhibitor (IC50 = 0.67 µM) which displays much reduced activities toward other PDE4 isoforms. It is shown to cause a significant 40% increase in extracellular cAMP in the hippocampus of freely moving rats in vivo at 100 µM, but has no effect on Aβ levels. This compound elicits cognitive enhancement in vivo at the optimum dose of 0.003 mg/kg in both mice and rat models, and unlike rolipram, does not cause emesis-like behavior in rodents.
      Catalogue Number524748
      Brand Family Calbiochem®
      SynonymsGEBR-7b, (E)-3-(cyclopentyloxy)-4-methoxybenzaldehyde, O-2-(2,6-dimethylmorpholino)-2-oxoethyl oxime
      References
      ReferencesBruno, O., et al. 2011. Br. J. Pharmacol. in press.
      Bruno, O., et al. 2009. J. Med. Chem. 52, 6546.
      Product Information
      FormPale yellow semi-solid
      Hill FormulaC₂₁H₃₀N₂O₅
      Chemical formulaC₂₁H₃₀N₂O₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      PDE4D Inhibitor, GEBR-7b - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PDE4D Inhibitor, GEBR-7b - Calbiochem Certificates of Analysis

      TitleLot Number
      524748

      References

      Reference overview
      Bruno, O., et al. 2011. Br. J. Pharmacol. in press.
      Bruno, O., et al. 2009. J. Med. Chem. 52, 6546.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-June-2012 JSW
      SynonymsGEBR-7b, (E)-3-(cyclopentyloxy)-4-methoxybenzaldehyde, O-2-(2,6-dimethylmorpholino)-2-oxoethyl oxime
      DescriptionA cell permeable, potent, and selective oxime PDE4D inhibitor (IC50 = 0.67 µM) which displays much reduced activities toward other PDE4 isoforms. It is shown to cause a significant 40% increase in extracellular cAMP in the hippocampus of freely moving rats in vivo at 100 µM, but has no effect on Aβ levels. This compound elicits cognitive enhancement in vivo at the optimum dose of 0.003 mg/kg in both mice and rat models, and unlike rolipram, does not cause emesis-like behavior in rodents.
      FormPale yellow semi-solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₁H₃₀N₂O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml; clear, colorless solution)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBruno, O., et al. 2011. Br. J. Pharmacol. in press.
      Bruno, O., et al. 2009. J. Med. Chem. 52, 6546.