Key Specifications Table
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|497985-10MG||Glass bottle||10 mg|
|Overview||A cell-permeable pyridoxyl-ornithine compound that acts as an effective analog of the transition state coenzyme-substrate adduct during orthithine decarboxylase- (ODC) catalyzed conversion of L-orthithine to Pultrescine. POB is typically 5- to 10-fold more potent than DFMO (Cat. No. 288500) in inhibiting intracellular ODC activity and tumor cell growth in cultures, while exhibiting little effect against the growth of nontumorigenic human aortic smooth muscle cells.|
|Synonyms||N-(4ʹ-Pyridoxyl)-Ornithine(BOC)-OMe, ODC Inhibitor, POB|
|References||Wu, F., et al. 2007. Mol. Cancer Ther. 6, 1831.|
|Form||White to off-white solid|
|Formulation||Supplied as a hydrochloride salt.|
|Structure formula Image|
|Purity||≥95% by HPLC|
|Safety Information according to GHS|
|Product Usage Statements|
|Packaged under inert gas||Packaged under inert gas|
|Wu, F., et al. 2007. Mol. Cancer Ther. 6, 1831.|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.