497985 Ornithine Decarboxylase Inhibitor, POB - Calbiochem

497985
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₉H₃₁N₃O₆

Pricing & Availability

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497985-10MG
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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable pyridoxyl-ornithine compound that acts as an effective analog of the transition state coenzyme-substrate adduct during orthithine decarboxylase- (ODC) catalyzed conversion of L-orthithine to Pultrescine. POB is typically 5- to 10-fold more potent than DFMO (Cat. No. 288500) in inhibiting intracellular ODC activity and tumor cell growth in cultures, while exhibiting little effect against the growth of nontumorigenic human aortic smooth muscle cells.
      Catalogue Number497985
      Brand Family Calbiochem®
      SynonymsN-(4ʹ-Pyridoxyl)-Ornithine(BOC)-OMe, ODC Inhibitor, POB
      References
      ReferencesWu, F., et al. 2007. Mol. Cancer Ther. 6, 1831.
      Product Information
      FormWhite to off-white solid
      FormulationSupplied as a hydrochloride salt.
      Hill FormulaC₁₉H₃₁N₃O₆
      Chemical formulaC₁₉H₃₁N₃O₆
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ornithine Decarboxylase Inhibitor, POB - Calbiochem Certificates of Analysis

      TitleLot Number
      497985

      References

      Reference overview
      Wu, F., et al. 2007. Mol. Cancer Ther. 6, 1831.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-July-2018 JSW
      SynonymsN-(4ʹ-Pyridoxyl)-Ornithine(BOC)-OMe, ODC Inhibitor, POB
      DescriptionA cell-permeable pyridoxyl-ornithine compound that acts as an effective analog of the transition state coenzyme-substrate adduct during orthithine decarboxylase- (ODC) catalyzed conversion of L-orthithine to Pultrescine. POB is typically 5- to 10-fold more potent than DFMO (Cat. No. 288500) in inhibiting intracellular ODC activity and tumor cell growth in cultures, while exhibiting little effect against the growth of nontumorigenic human aortic smooth muscle cells.
      FormWhite to off-white solid
      FormulationSupplied as a hydrochloride salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₉H₃₁N₃O₆
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesWu, F., et al. 2007. Mol. Cancer Ther. 6, 1831.