370681 OXE-R-Gβγ Coupling Modulator, Gue1654 - Calbiochem

370681
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370681-25MG
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      Glass bottle 25 mg
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      Description
      OverviewA membrane-permeant amidobenzobisthiazolo compound that modulates OXE-R-Gβγ coupling upon receptor stimulation via direct OXE-R interaction, without affecting preexisting OXE-R-Gαβ interaction. Selectively inhibits OXE-R-Gβγ coupling-mediated, but not OXE-R-Gα-mediated, downstream cellular signalings (Effective Conc. 1 to 30 µM), displaying no inhibitory activity against cellular functions mediated by Gα or Gβγ when coupled to other GPCRs. Comparing to Gallein (Cat. No. 371708), Gue1654 does not exert its activity via direct Gβγ interaction.
      Catalogue Number370681
      Brand Family Calbiochem®
      Synonyms7-(Methylthio)-2-((2,2-diphenylacetyl)amino)benzo[1,2-d:4,3-dʹ]bisthiazole, N-(7-(Methylsulfanyl)[1,3]thiazolo[4,5-g][1,3]benzothiazol-2-yl)-2,2-diphenylacetamide
      References
      ReferencesBlattermann, S., et al. 2012. Nat. Chem. Biol. 8, 631.
      Product Information
      FormTan solid
      Hill FormulaC₂₃H₁₇N₃OS₃
      Chemical formulaC₂₃H₁₇N₃OS₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target OXE-R-Gβγ coupling
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      OXE-R-Gβγ Coupling Modulator, Gue1654 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Blattermann, S., et al. 2012. Nat. Chem. Biol. 8, 631.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-April-2013 JSW
      Synonyms7-(Methylthio)-2-((2,2-diphenylacetyl)amino)benzo[1,2-d:4,3-dʹ]bisthiazole, N-(7-(Methylsulfanyl)[1,3]thiazolo[4,5-g][1,3]benzothiazol-2-yl)-2,2-diphenylacetamide
      DescriptionA membrane-permeant amidobenzobisthiazolo compound that modulates OXE-R-Gβγ coupling upon receptor stimulation via direct OXE-R interaction, but not preexisting OXE-R-Gαβ interaction. Shown to selectively inhibit OXE-R-Gβγ coupling-mediated, but not OXE-R-Gα-mediated, downstream signalings in HEK293 as well as primary human eosinophils and neutrophils (Effective Conc. 1 to 30 µM), displaying no inhibitory activity against cellular functions mediated by Gα or Gβγ when coupled to other GPCRs, including PGD2 receptor CRTH2 (DP2), IL8 receptors CXCR1/2, muscarinic receptor, and C5a receptor. Comparing to Gallein (Cat. No. 371708), Gue1654 does not exert its activity via direct Gβγ interaction.
      FormTan solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₃H₁₇N₃OS₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesBlattermann, S., et al. 2012. Nat. Chem. Biol. 8, 631.