GF173 Noggin Protein, Human Recombinant

GF173
20 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      SourcePurity
      HEK293 cells Product is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 95% pure by SDS-PAGE gel and HPLC analyses
      Description
      Catalogue NumberGF173
      DescriptionNoggin Protein, Human Recombinant
      Alternate Names
      • NOG
      • SYM1
      • SYNS1
      Background InformationNoggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant human Noggin is a 46 kDa disulfide-linked homodimer (120-10C) consisting of two 206 amino acid polypeptide chains. Monomeric glycosylated Noggin migrates at an apparent molecular weight of approximately 28.0-33.0 kDa by SDS PAGE analysis under reducing conditions.
      References
      Product Information
      PresentationProduct is filtered through a 0.2 micron filter before lyophilization.
      Quality LevelMQ100
      Applications
      ApplicationThe human Noggin recombinant protein belongs to a group of diffusible proteins which bind to ligands of the TGF-β family & regulate their activity by inhibiting their access to signaling receptors.
      Biological Information
      PurityProduct is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 95% pure by SDS-PAGE gel and HPLC analyses
      SourceHEK293 cells
      Cross ReactivityMouse, Chicken
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceBioactivity assay: Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC chondrogenic cells. The expected ED50 for this effect is 2.0-3.0 ng/ml of Noggin.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C for up to 6 months from date of receipt.
      Packaging Information
      Material Size20 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Noggin Protein, Human Recombinant SDS

      Title

      Safety Data Sheet (SDS) 

      Noggin Protein, Human Recombinant Certificates of Analysis

      TitleLot Number
      Recombinant Human NOGGIN - 21370602137060
      Recombinant Human NOGGIN - 23735112373511
      Recombinant Human NOGGIN - 24248302424830
      Recombinant Human -26185242618524
      Recombinant Human -26574902657490
      Recombinant Human -26848482684848
      Recombinant Human -27106112710611
      Recombinant Human -27288652728865
      Recombinant Human -27788522778852
      Recombinant Human NOGGIN - 20654552065455

      Related Products & Applications

      Product Families

      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors